The Brain NGF Metabolic Pathway in Health and in Alzheimer's Pathology

Frontiers in Neuroscience
A Claudio CuelloHélène Hall

Abstract

Emerging research has re-emphasized the role of the cortical cholinergic system in the symptomology and progression of Alzheimer's disease (AD). Basal forebrain (BF) cholinergic nuclei depend on target-derived NGF for survival during development and for the maintenance of a classical cholinergic phenotype during adulthood. In AD, BF cholinergic neurons lose their cholinergic phenotype and function, suggesting an impairment in NGF-mediated trophic support. We propose that alterations to the enzymatic pathway that controls the maturation of proNGF to mature NGF and the latter's ulterior degradation underlie this pathological process. Indeed, the NGF metabolic pathway has been demonstrated to be impaired in AD and other amyloid pathologies, and pharmacological manipulation of NGF metabolism has consequences in vivo for both levels of proNGF/NGF and the phenotype of BF cholinergic neurons. The NGF pathway may also have potential as a biomarker of cognitive decline in AD, as its changes can predict future cognitive decline in patients with Down syndrome as they develop preclinical Alzheimer's pathology. New evidence suggests that the cholinergic system, and by extension NGF, may have a greater role in the progression of AD than prev...Continue Reading

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Citations

Jan 19, 2020·Journal of Neural Transmission·A Claudio Cuello
Dec 5, 2019·Cerebral Cortex·Jose L CanteroUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 19, 2020·Scientific Reports·Lorna GuéniotGrégory Jouvion
Oct 23, 2019·Neural Regeneration Research·Diego La Mendola
Sep 29, 2020·Developmental Neuropsychology·Yanin Santoya-MontesPedro Puentes Rozo
Apr 21, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Sasimol UdomrukPrachya Kongtawelert
Apr 17, 2020·Frontiers in Immunology·Harald HampelSimone Lista
Nov 19, 2019·Frontiers in Aging Neuroscience·Puneet TalwarRachna Agarwal
Nov 24, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rowan PentzA Claudio Cuello
Jan 30, 2021·Neural Regeneration Research·Gemma EftimiadiAntonio Chiaretti
Apr 6, 2021·Journal of Alzheimer's Disease : JAD·Gustaf BoströmMartin Ingelsson
May 5, 2021·Journal of Neural Transmission·Filippo Sean GiorgiFrancesco Fornai
Jun 30, 2021·Clinical Proteomics·Angelique Florentinus-MefailoskiJohn G Marshall
Jul 3, 2021·International Journal of Molecular Sciences·Suzanne GasconNathalie Faucheux
Jul 31, 2021·Frontiers in Aging Neuroscience·Anna GasiorowskaGrazyna Niewiadomska
Aug 27, 2021·Frontiers in Aging Neuroscience·Sonia Do CarmoA Claudio Cuello
Sep 4, 2021·Frontiers in Aging Neuroscience·Sumonto MitraJaan-Olle Andressoo
Nov 27, 2021·Molecular Biology Reports·Ava NasrolahiZahra Shabani
Jun 10, 2021·Current Alzheimer Research·Chiara BurgalettoGiuseppina Cantarella

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Methods Mentioned

BETA
transgenic

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