PMID: 16617391Apr 18, 2006Paper

The brain scintiscan with iodine-123-ioflupane to diagnose early Parkinson's disease; seven months follow up. First results in Bulgaria

Hellenic journal of nuclear medicine
Elena PiperkovaMaria Dimitrova

Abstract

The aim of this study was to evaluate the brain scintiscan images with (123)I-ioflupane for the diagnosis of patients with early Parkinson's disease (PD). Sixteen patients were studied, nine males and seven females, aged between 38-81 y (mean age: 64 y). All patients underwent thyroid blocking by oral administration of 120 mg potassium iodide before and 24 h after the intravenous (iv) injection of 110-185 MBq/70 kg patient's weight, of (123)I-ioflupane. To check the correct biodistribution of the radiopharmaceutical, whole-body scans were performed at 15 min and 2-3 h after the administration of the radiopharmaceutical. All patients underwent brain single photon emission tomography (SPET) scans on a SPET gamma-camera 3-5 h after (123)I-ioflupane administration. To compensate for scatter and to avoid artifacts, the filtering and reconstructing procedures of the images were performed individually for each patient. Brain SPET results were evaluated semi-quantitatively using different indices. The morphology of the nigrostriatum (NS) area was also examined visually. The (123)I-ioflupane uptake by the affected nigrostriatum (ANS) was compared to a similar area at the occipital (Occ) brain section and to a similar area at the opposit...Continue Reading

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