The brain, sirtuins, and ageing

Nature Reviews. Neuroscience
Akiko SatohLeonard Guarente

Abstract

In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level. CNS decline drives the progressive impairment of cognitive, social and physical abilities, and the mechanisms underlying CNS regulation of the ageing process, such as microglia-neuron networks and the activities of sirtuins, a class of NAD(+)-dependent deacylases, are beginning to be understood. Such mechanisms are potential targets for the prevention or treatment of age-associated dysfunction and for the extension of a healthy lifespan.

References

Jan 1, 1988·Audiology : Official Organ of the International Society of Audiology·R J SweetK R Henry
Sep 26, 1994·Neuroscience Letters·W A BanksE G Gutierrez
Sep 1, 1993·Journal of Neuroimmunology·E G GutierrezA J Kastin
Mar 1, 1996·Brain Research. Molecular Brain Research·J F Poduslo, G L Curran
Mar 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R Miskin, T Masos
Jun 1, 1997·Journal of Neuroimmunology·W PanA J Kastin
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Apr 3, 2001·Journal of Neuroimmunology·W Pan, A J Kastin
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Alan Peters
Jan 25, 2003·Science·Matthias BlüherC Ronald Kahn
Jan 30, 2003·Psychosomatic Medicine·Mary Amanda DewCharles F Reynolds
May 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xinyu ZhaoFred H Gage
Dec 19, 2003·Journal of the American College of Cardiology·Robert J ScheubelAndreas Simm
Sep 24, 2004·The Journal of Biological Chemistry·Javier R RevolloShin-ichiro Imai
Mar 15, 2005·Brain Research Bulletin·Mikael NygårdKrister Kristensson
Mar 29, 2005·Nature Genetics·J Alex ParkerChristian Néri
May 26, 2005·Progress in Neurobiology·Jason G EmsleyJeffrey D Macklis
May 28, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P GodboutR W Johnson
Sep 15, 2005·Neuroscience Letters·Angela M WongCaleb E Finch
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Sep 27, 2005·The Journal of Biological Chemistry·Jennifer ChenLi Gan
Sep 20, 2006·Journal of Neurochemistry·Rebecca GriffinMarina A Lynch
Feb 13, 2007·Neuroscience·M LetiembreK Fassbender
Jun 1, 2007·Nature·Nicholas A Bishop, Leonard Guarente
Jun 26, 2007·Science·Tiago Fleming OuteiroAleksey G Kazantsev
Jul 21, 2007·Science·Akiko TaguchiMorris F White
Aug 9, 2007·Nature Reviews. Molecular Cell Biology·Steven J Russell, C Ronald Kahn

❮ Previous
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Citations

Nov 9, 2017·International Journal of Environmental Research and Public Health·Nicola Magnavita, Sergio Garbarino
Sep 28, 2017·The Journal of Physiology·Michael J Berridge
Jun 17, 2018·Journal of Pineal Research·Rubén CorpasBárbara R Cardoso
Aug 18, 2018·Nature Reviews. Drug Discovery·Barry BolandMark J Millan
May 28, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Devin WahlDavid G Le Couteur
Sep 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Puneet BaggaRavinder Reddy
Nov 26, 2019·Rejuvenation Research·James Larrick, Andrew R Mendelsohn
Feb 6, 2020·Nature Reviews. Molecular Cell Biology·Weiqi ZhangJuan Carlos Izpisua Belmonte
Oct 23, 2019·Annual Review of Physiology·Christi M GendronScott D Pletcher
Feb 19, 2020·Proteomics·Rishi Sharma, Arvind Ramanathan
May 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ligen ShiYejie Shi
Oct 3, 2018·Communications Biology·Diankun YuLaura A Schrader
Mar 25, 2019·Experimental & Molecular Medicine·Jiyun KwonIn Hye Lee
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Naazneen KhanAjit Varki
Sep 30, 2020·Bulletin of Experimental Biology and Medicine·A A SpirichevP M Masliukov
Nov 6, 2018·Journal of Clinical Medicine·Oh Yoen Kim, Juhyun Song
Oct 18, 2019·Nature·Joseph M ZulloBruce A Yankner
Sep 16, 2020·Cardiovascular Research·Luca LiberaleGiovanni G Camici
Dec 17, 2020·Medicinal Research Reviews·Gang LiuJia Zhou
Jan 5, 2021·Frontiers in Aging Neuroscience·Bernard CuenoudLijing Xin
Jan 15, 2021·Neurochemistry International·Hitomi MatsunoKazuhiro Sohya
Nov 17, 2019·Ageing Research Reviews·Jiao LuoDiana van Heemst
Feb 6, 2021·Cell Death & Disease·Ting ZhaoJun Chen
Mar 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiMasoud Najafi
Apr 4, 2021·International Journal of Molecular Sciences·Noemi Sola-SevillaElena Puerta
Apr 3, 2021·IScience·Mehrshad Sadria, Anita T Layton
Aug 12, 2020·Mechanisms of Ageing and Development·Amanda J Audesse, Ashley E Webb
May 17, 2021·Neurochemistry International·Jean Lud Cadet, Subramaniam Jayanthi
May 30, 2020·Current Opinion in Physiology·Laura E McKillop, Vladyslav V Vyazovskiy
Apr 6, 2021·Aging and Disease·Sandra Fuertes-Alvarez, Ander Izeta
Dec 8, 2020·ACS Chemical Neuroscience·Keng Yoon YeongYuin Chang

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