PMID: 8946335Nov 6, 1996Paper

The brainstem network involved in coordination of inspiratory activity and cholinergic outflow to the airways

Journal of the Autonomic Nervous System
M A HaxhiuN S Cherniack

Abstract

The respiratory rhythm modulates cholinergic outflow to the tracheal smooth muscle through the parasympathetic nerves. To determine the basis of this modulation, we combined the retrograde tracer technique to identify bulbospinal cells projecting to phrenic motoneurons, and the transneuronal labeling method to visualize medullary neurons that innervate airway-related vagal preganglionic cells. Following injections of fluorogold into the ventral horns of the cervical spinal cord and injections of pseudorabies virus (PRV) into the wall of the extrathoracic trachea of superior cervical ganglioctomized Sprague-Dawley rats. A large number of the double-labeled cells were identified along the ventral aspect of the medulla oblongata. Most frequently, double-labeled neurons were seen in the medial tegmental field, particularly in the parapyramidal region, within the gigantocellular nuclei, and the caudal raphe nuclei. Less frequently, double-labeled neurons were found in the ventrolateral medulla. No double-labeled cell was observed in the dorsal aspect of the medulla oblongata. This study indicates that a subset of medullary neurons that project to phrenic motoneurons also innervate the airway-related vagal preganglionic cells, allowi...Continue Reading

References

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Feb 5, 1996·Journal of the Autonomic Nervous System·M A Haxhiu, A D Loewy

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Citations

May 22, 2007·Current Gastroenterology Reports·Christopher SlocumSusan R Orenstein
Feb 28, 1998·Journal of the Autonomic Nervous System·M A HaxhiuI A Dreshaj
Jul 22, 1998·Journal of the Autonomic Nervous System·M A HaxhiuI A Dreshaj
Mar 4, 2000·Journal of the Autonomic Nervous System·G CanoA F Sved
Oct 12, 2001·Autonomic Neuroscience : Basic & Clinical·G J Ter Horst
Oct 5, 2007·Journal of Neurophysiology·Kevin M HellmanPeggy Mason
Jun 27, 2002·Pediatric Research·Pakaphan KiatchoosakunRichard J Martin
Jul 27, 1999·The Journal of Physiology·B S Kesler, B J Canning
May 31, 2011·Respiratory Physiology & Neurobiology·Dongying QiuJijiang Wang
Apr 3, 2010·Respiratory Physiology & Neurobiology·Prabha Kc, Richard J Martin
Mar 1, 2005·Respiratory Physiology & Neurobiology·Mingfei WuShereé M Johnson
Jul 6, 2004·Respiratory Physiology & Neurobiology·Ozra DehkordiSyed I Zaidi
Jul 27, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T S MoreiraF P Zolezi
Aug 18, 2005·Journal of Neurophysiology·Peggy Mason
Oct 29, 2005·The Journal of Comparative Neurology·Peggy Mason
May 17, 2005·Journal of Applied Physiology·Musa A HaxhiuDonald G Ferguson
Dec 18, 2001·Journal of Applied Physiology·Luke A HendersonRonald M Harper
Sep 27, 2020·Journal of Neuroscience Methods·Maohui FengHongBing Xiang

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