The BRCA1 syndrome and other inherited breast or breast-ovarian cancers in a Norwegian prospective series

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P MøllerNorwegian Inherited Ovarian Cancer Group

Abstract

Inherited breast cancer is a heterogenous group of diseases. We examined this heterogeneity in a prospective series of inherited breast and ovarian cancers, previously demonstrated to include 84% of inherited cancers. Ninety-two tumours (65 breast and 27 ovarian) in 82 patients from 70 kindreds were prospectively diagnosed. Fifteen of the breast cancers were in situ, 50 were infiltrating. 40 (49%) of the 82 women carried a BRCA1 mutation, whereas no mutation in BRCA2 was found. Approximately, two-thirds of the BRCA1 mutation carriers had one of the four most frequent Norwegian founder mutations. Ninety-five per cent of the epithelial ovarian cancers occurred in BRCA1 mutation carrying women versus 38% of infiltrating breast cancers and 7% of carcinoma in situ of the breast. The BRCA1 syndrome was phenotypically distinct with invasive, high grade, oestrogen receptor-negative breast cancers and epithelial ovarian cancers. Non-BRCA1/2 inherited breast cancers included carcinoma in situ and lobular carcinoma and were frequently bilateral. Non-BRCA1/2 inherited breast cancer is not associated with epithelial ovarian cancer and in breast cancers has distinct biological characteristics, indicating that the different subgroups of inher...Continue Reading

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Citations

Mar 21, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Amy Østertun GeirdalAlv A Dahl
Jun 29, 2002·Cancer Detection and Prevention·Ketil HeimdalPål Møller
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P MøllerUNKNOWN Norwegian Inherited Ovarian Cancer Group
Jan 1, 2004·Hereditary Cancer in Clinical Practice·Pål Møller
Jan 1, 2007·Hereditary Cancer in Clinical Practice·Pål MøllerJaran Apold
Oct 20, 2015·Molecular Diagnosis & Therapy·Elisabete Weiderpass, Jerzy E Tyczynski
Dec 24, 2005·Scandinavian Journal of Gastroenterology·Astrid T StormorkenPål Møller
Sep 19, 2002·International Journal of Cancer. Journal International Du Cancer·Pål MøllerKetil Heimdal
May 2, 2007·International Journal of Cancer. Journal International Du Cancer·Pal MollerC Michael Steel
Apr 17, 2003·British Journal of Cancer·UNKNOWN Scottish/Northern Irish BRCAI/BRCA2 Consortium
Jan 18, 2018·Hereditary Cancer in Clinical Practice·Cecilie HerambLovise Mæhle
Feb 5, 2004·Journal of Genetic Counseling·Trine Levin BoddPal Moller
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lovise MaehlePål Møller

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European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Ketil HeimdalP Møller
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P MøllerNorwegian Inherited Ovarian Cancer Group
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