The brinker gradient controls wing growth in Drosophila

Development
Francisco A MartínG Morata

Abstract

The Decapentaplegic (Dpp) morphogen gradient controls growth and patterning in the Drosophila appendages. There is recent evidence indicating that the Dpp gradient is converted into an inverse gradient of activity of the gene brinker (brk), which encodes a transcriptional repressor and is negatively regulated by the Dpp pathway. We have studied how alterations in the Brk gradient affect the growth of the wing disc. We find that there is a negative correlation between brk activity and growth of the disc: high levels of brk prevent or reduce growth, whereas loss of brk activity results in excessive growth. This effect is concentration dependent: different amounts of Brk produce distinct rates of growth. Furthermore, our results demonstrate that although brk is able to induce apoptosis where there is a sharp difference in Brk levels, its role as a growth repressor is not achieved by inducing apoptosis but by reducing cell proliferation. Brk appears to downregulate the activity of genes that control cell proliferation, such as bantam.

References

Jan 1, 1976·Annual Review of Genetics·W J Gehring
Sep 10, 1976·Science·V FrenchS V Bryant
Feb 1, 1975·Developmental Biology·G Morata, P Ripoll
Jan 1, 1971·Developmental Biology·A Garcia-Bellido, J R Merriam
Oct 1, 1971·Developmental Biology·A Garcia-Bellido, J R Merriam
Dec 1, 1984·The Quarterly Review of Biology·P J Bryant, P Simpson
Oct 11, 1996·Science·M CallejaG Morata
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·M MilánA García-Bellido
Jun 8, 1999·Developmental Biology·L A Raftery, D J Sutherland
Aug 12, 1999·Seminars in Cell & Developmental Biology·M Strigini, S M Cohen
Sep 28, 1999·Trends in Genetics : TIG·S D Podos, E L Ferguson
Sep 12, 2000·Current Opinion in Genetics & Development·H Stocker, E Hafen
Oct 12, 2000·Nature Cell Biology·T MartyM Affolter
Jan 4, 2001·Cell·A A Teleman, S M Cohen
Jan 4, 2001·Cell·E V EntchevM González-Gaitán
Aug 3, 2001·Nature Reviews. Genetics·T Tabata
Jul 20, 2002·Genes & Development·Elisabeth SallerMariann Bienz
Aug 28, 2002·Genetics·David R HipfnerStephen M Cohen
Nov 5, 2002·Developmental Biology·Takashi Adachi-Yamada, Michael B O'Connor
Nov 8, 2002·Development·Madhuri Kango-SinghGeorg Halder
Aug 28, 2003·Nature Cell Biology·Laura A Johnston, Angela L Sanders
Sep 23, 2003·Nature Cell Biology·Ryan S UdanGeorg Halder

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Citations

Dec 21, 2006·Journal of Mathematical Biology·R E Baker, P K Maini
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·A Guillon-MunosP G H Clarke
Mar 15, 2006·Apoptosis : an International Journal on Programmed Cell Death·V Zuzarte-LuisJ M Hurlé
Aug 12, 2008·Apoptosis : an International Journal on Programmed Cell Death·M L EscobarG H Vázquez-Nin
Feb 9, 2012·Protein & Cell·Claire Gordy, You-Wen He
Jan 11, 2008·Nature Reviews. Cancer·Eduardo Moreno
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Gerald Schwank, Konrad Basler
Jan 28, 2012·Science·Gerald SchwankKonrad Basler
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Ricardo M Neto-SilvaLaura A Johnston
Sep 6, 2012·Development·Giri Raj DahalEmily Bates
Nov 18, 2006·Genetics·David M TylerNicholas E Baker
Aug 16, 2011·Journal of Mechanics of Materials and Structures·A D LanderF Y M Wan
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ainhoa Pérez-GarijoGinés Morata
Nov 10, 2015·Nature·Stefan HarmansaEmmanuel Caussinus
Dec 12, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Seba Jamal Shbailat, Ehab Abouheif
Jan 23, 2013·EMBO Reports·Nikolaos DoumpasAurelio A Teleman
Oct 18, 2005·Current Opinion in Cell Biology·Sally J Leevers, Helen McNeill
Jun 1, 2005·Experimental Cell Research·Begoña Díaz, Eduardo Moreno
Sep 25, 2015·Nucleic Acids Research·María Pilar de LucasEncarnación Lozano
Jan 27, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexis Matamoro-VidalDavid Houle
Dec 9, 2014·Nucleus·Allison JamesPatrick DiMario
Sep 5, 2006·Current Biology : CB·Riitta NoloGeorg Halder
Mar 22, 2014·Current Biology : CB·Simon RestrepoKonrad Basler
Jan 18, 2011·Developmental Cell·Hyangyee Oh, Kenneth D Irvine
Nov 5, 2005·Cell·Dragana Rogulja, Kenneth D Irvine
May 9, 2014·Seminars in Cell & Developmental Biology·Ludovic Baillon, Konrad Basler
May 13, 2014·Seminars in Cell & Developmental Biology·Fisun HamaratogluGeorge Pyrowolakis
Jan 3, 2009·Mechanisms of Development·David ForondaFrancisco A Martín
Sep 21, 2005·Developmental Biology·Melissa Moser, Gerard Campbell
Mar 6, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Julien BéhagueMathieu Molet

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