The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice

Neurotoxicology
L G CostaPamela J Roque

Abstract

Polybrominated diphenyl ethers (PBDEs), used for decades as flame retardants, have become widespread environmental contaminants. Exposure is believed to occur primarily through diet and dust, and infants and toddlers have the highest body burden, raising concern for potential developmental neurotoxicity. The exact mechanisms of PBDE neurotoxicity have not been elucidated, but two relevant modes of action relate to impairment of thyroid hormone homeostasis and to direct effects on brain cells causing alterations in signal transduction, oxidative stress and apoptotic cell death. The present study shows that BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) induces oxidative stress and ensuing apoptotic cell death in mouse cerebellar granule neurons in vitro. Similarly, in vivo administration of BDE-47, according to an exposure protocol shown to induce behavioral and biochemical alterations (10mg/kg, per os on post-natal day 10), induces oxidative stress and apoptosis, without altering serum levels of thyroid hormones. The effects of BDE-47 both in vitro and in vivo were more pronounced in a mouse model lacking the modifier subunit of glutamate cysteine ligase (GCLM) which results in reduced anti-oxidant capability due to low levels of ...Continue Reading

References

Jan 1, 1994·Methods in Enzymology·R L LevineE Shacter
Oct 24, 2001·Environmental Health Perspectives·P ErikssonA Fredriksson
Feb 28, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tong ZhouKevin M Crofton
Jul 5, 2003·Environmental Health Perspectives·Anita MazdaiRobert M Bigsby
Oct 13, 2004·Free Radical Biology & Medicine·Timothy P DaltonHoward G Shertzer
Jan 13, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniele F StaskalLinda S Birnbaum
Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Klas BlomgrenLaurent Groc
Jun 1, 2007·Acta Paediatrica·Augusto SolaRichard Deulofeut
Sep 7, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gennaro GiordanoLucio G Costa
Oct 2, 2007·Neurotoxicology·Lucio G Costa, Gennaro Giordano
Jan 8, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Peter G WellsAndrea W Wong
Jan 22, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaharu Hayashi
Sep 2, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sara TagliaferriLucio G Costa
Sep 15, 2009·Environmental Health Perspectives·Leisa-Maree L TomsJochen F Mueller
Dec 9, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Suping C HuangLucio G Costa
Jan 2, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Milou M L DingemansRemco H S Westerink
Jan 9, 2010·Environmental Health Perspectives·Julie B HerbstmanFrederica Perera
Jun 15, 2010·Birth Defects Research. Part C, Embryo Today : Reviews·Peter G WellsStephanie L Ondovcik
Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Amy Lavin Williams, John M DeSesso
Sep 11, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sten OrreniusBoris Zhivotovsky
Feb 15, 2011·Drug and Chemical Toxicology·Jillian R GeeDavid W Herr
Aug 5, 2011·Methods in Molecular Biology·Dejan MilatovicMichael Aschner
Aug 23, 2011·Pediatric Research·How-Ran ChaoGou-Ping Chang-Chien
Nov 18, 2011·International Journal of Hygiene and Environmental Health·Cherng-Gueih ShyGou-Ping Chang-Chien
Feb 22, 2012·Human Molecular Genetics·Rima WoodsJanine M LaSalle
Oct 2, 2012·Neurotoxicology and Teratology·Claire M KoenigRobert F Berman

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Citations

May 29, 2016·Toxicology·Lilian Cristina PereiraDaniel Junqueira Dorta
Jun 15, 2016·Journal of Toxicology and Environmental Health. Part a·Santokh GillWayne Bowers
Sep 3, 2016·Journal of Applied Toxicology : JAT·Anna Karpeta, Ewa Łucja Gregoraszczuk
Apr 10, 2016·Basic & Clinical Pharmacology & Toxicology·Lílian Cristina PereiraDanielle Palma de Oliveira
Nov 5, 2016·Expert Review of Proteomics·Shankar SumanYogeshwer Shukla
Feb 22, 2017·Luminescence : the Journal of Biological and Chemical Luminescence·Lulu YangZhongsheng Yi
Jun 7, 2016·Neurotoxicology·Jeanette Therming JørgensenZorana Jovanovic Andersen
Oct 24, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·David C DormanKatrina M Waters
Sep 12, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joshua F RobinsonSusan J Fisher
Feb 24, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Noriko KanayaShiuan Chen
Jun 8, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hao ChenJoshua F Robinson
Aug 3, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wesley A Gray, Vincent A Billock
Apr 13, 2019·Acta Neuropathologica·Isaac N PessahSharon K Sagiv
Dec 18, 2015·Molecular Neurobiology·Shun ZhangAiguo Wang
Nov 28, 2019·Journal of Alzheimer's Disease : JAD·Puja AgarwalMartha C Morris
Nov 5, 2019·Ecotoxicology and Environmental Safety·Nilce Mary Turcatti FolleCiro Alberto de Oliveira Ribeiro

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