The Brown Norway rat displays enhanced stress-induced ACTH reactivity at day 18 after 24-h maternal deprivation at day 3

Brain Research. Developmental Brain Research
J O WorkelE R De Kloet

Abstract

The effect of a 24-h maternal deprivation at day 3 was studied on the hypothalamus-pituitary-adrenal axis of 18-day-old Brown Norway pups, whose stress-hyporesponsive period is similar to other rat strains. Deprivation resulted at day 18 in reduced basal ACTH levels. The rate of onset and the duration of stress-induced ACTH release were enhanced. CRH mRNA, brain corticosteroid mRNA levels and corticosterone receptor levels were not affected by deprivation, but adrenal weight was increased. It is concluded that maternal deprivation has persistently diminished adrenocortical function in containment of the ACTH response to stress.

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Citations

Nov 19, 2010·Psychopharmacology·Mathias V SchmidtOnno C Meijer
Dec 5, 1998·Brain Research. Developmental Brain Research·H J van OersS Levine
Oct 17, 2001·Experimental Gerontology·P Huijbers, D L Knook
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Nov 10, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L EnthovenM S Oitzl
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Melly S OitzlE Ronald de Kloet
Aug 6, 2005·The Journal of Nervous and Mental Disease·Karin RoelofsKees A L Hoogduin

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