PMID: 11925998Apr 3, 2002Paper

The Brugia malayi genome project: expressed sequence tags and gene discovery

Transactions of the Royal Society of Tropical Medicine and Hygiene
Mark L BlaxterFilarial Genome Project

Abstract

To advance and facilitate molecular studies of Brugia malayi, one of the causative agents of human lymphatic filariasis, an expressed sequence tag (EST)-based gene discovery programme has been carried out. Over 22,000 ESTs have been produced and deposited in the public databases by a consortium of laboratories from endemic and non-endemic countries. The ESTs have been analysed using custom informatic tools to reveal patterns of individual gene expression that may point to potential targets for future research on anti-filarial drugs and vaccines. Many genes first discovered as ESTs are now being analysed by researchers for immunodiagnostic, vaccine and drug target potential. Building on the success of the B. malayi EST programme, significant EST datasets are being generated for a number of other major parasites of humans and domesticated animals, and model parasitic species.

References

May 1, 1992·Nature Genetics·R WaterstonN Halloran
Sep 1, 1989·Molecular and Biochemical Parasitology·A L ScottS Ward
Feb 1, 1994·Current Opinion in Biotechnology·J R McCarrey, S A Williams
Mar 1, 1995·Molecular and Biochemical Parasitology·A L ScottN Raghavan
Mar 1, 1995·Molecular and Biochemical Parasitology·S A MartinE Devaney
May 1, 1995·Infection and Immunity·P Yenbutr, A L Scott
Aug 1, 1994·Veterinary Parasitology·R Prichard
Jan 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Z Kaprielian, P H Patterson
Mar 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I L Johnstone
Jan 1, 1996·International Archives of Allergy and Immunology·J E Allen, R M Maizels
Nov 1, 1995·Molecular and Biochemical Parasitology·M SironiC Genchi
Apr 1, 1996·Molecular and Biochemical Parasitology·M L BlaxterA L Scott
Jul 1, 1996·Molecular and Biochemical Parasitology·S A MartinE Devaney
Aug 1, 1996·Molecular and Biochemical Parasitology·T A MooreT B Nutman
Jul 1, 1997·Molecular and Biochemical Parasitology·W F GregoryR M Maizels
Feb 12, 1998·Scientific American·T Beardsley
Mar 13, 1998·Molecular and Biochemical Parasitology·L KlimowskiC A Tripp
May 5, 1998·Molecular and Biochemical Parasitology·I GhoshA L Scott
Jul 4, 1998·Parasite Immunology·J E Allen, A S MacDonald
Oct 8, 1998·Molecular and Biochemical Parasitology·E M KeddieT R Unnasch
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Dec 16, 1998·Science·M Blaxter
Jan 28, 1999·Proceedings. Biological Sciences·C BandiM L Blaxter
Feb 24, 1999·Molecular and Biochemical Parasitology·Z BinP Hotez
Mar 31, 1999·Trends in Genetics : TIG·R K Wilson
Apr 8, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D A JohnstonS E Melville
Aug 31, 1999·Parasitology·M BlaxterJ Daub
Mar 25, 2000·Science·M D AdamsJ C Venter
Mar 25, 2000·International Journal for Parasitology·M Blaxter
Mar 25, 2000·International Journal for Parasitology·S A WilliamsM L Blaxter

❮ Previous
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Citations

Nov 21, 2007·Invertebrate Neuroscience : in·Katherine A SmithJohn Gray
Mar 24, 2004·International Journal for Parasitology·Maurizio CasiraghiClaudio Bandi
Apr 14, 2005·International Journal for Parasitology·Ross L Coppel, Casilda G Black
Apr 22, 2004·Trends in Parasitology·Elodie GhedinBarton E Slatko
Jun 12, 2003·Molecular and Biochemical Parasitology·A Aziz Aboobaker, Mark L Blaxter
Sep 22, 2005·Parasitology·G N GobertD P McManus
Dec 21, 2004·Nucleic Acids Research·José M Peregrín-AlvarezJohn Parkinson
Jun 11, 2005·Eukaryotic Cell·Stephen M BeverleyMichael R McNeil
Feb 11, 2012·Journal of Biomedical Science·Ramakrishna U RaoGary J Weil
May 1, 2008·PLoS Neglected Tropical Diseases·Judith E AllenDavid W Taylor
Jul 4, 2008·PLoS Neglected Tropical Diseases·James WasmuthMark Blaxter
Oct 30, 2008·PLoS Neglected Tropical Diseases·Yovany Moreno, Timothy G Geary
Jan 5, 2011·PLoS Neglected Tropical Diseases·Jonas LundströmJohan Lindh
Nov 15, 2007·PloS One·Sanjay KumarClotilde K S Carlow
Aug 4, 2006·The Journal of Parasitology·Wim BertGaëtan Borgonie
Nov 16, 2007·International Journal for Parasitology·Daojun JiangGary J Weil
May 1, 2007·Experimental Parasitology·Hak Sun YuHae Jin Jeong
Sep 14, 2004·Immunological Reviews·Rick M MaizelsJudith E Allen
Dec 4, 2003·Cellular Microbiology·Jane M Carlton
Nov 3, 2011·Parasite Immunology·M BlaxterB Elsworth
Sep 24, 2004·Molecular and Biochemical Parasitology·Makedonka MitrevaJames P McCarter
Jul 11, 2006·Molecular and Biochemical Parasitology·Ben-Wen LiMakedonka Mitreva
May 16, 2006·International Journal for Parasitology·Yong YinMakedonka Mitreva
Sep 13, 2005·Journal of Molecular Biology·Tarig B HigaziThomas R Unnasch
Mar 28, 2008·International Journal for Parasitology·Ana de OliveiraThomas R Unnasch
Dec 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrew K Jones, David B Sattelle
Jun 17, 2008·The Korean Journal of Parasitology·Hae Kyung ParkHak Sun Yu
Jul 1, 2005·Physiological Reviews·Scott L Hooper, Jeffrey B Thuma
Aug 16, 2005·Trends in Genetics : TIG·Makedonka MitrevaJames P McCarter
Sep 24, 2004·Molecular and Biochemical Parasitology·Claire WhittonMark Blaxter
Apr 19, 2003·Genome Biology·James P McCarterRobert H Waterston
Oct 28, 2008·Parasitology International·Alan L Scott, Elodie Ghedin
Oct 12, 2021·Expert Review of Vaccines·Vivek P ChavdaVandana Patravale

❮ Previous
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