The Bu Shen Yi Sui Formula Promotes Axonal Regeneration via Regulating the Neurotrophic Factor BDNF/TrkB and the Downstream PI3K/Akt Signaling Pathway

Frontiers in Pharmacology
Qi ZhengLei Wang

Abstract

Axonal damage is recognized as an important pathological feature in the chronic progressive neurological disorder multiple sclerosis (MS). Promoting axonal regeneration is a critical strategy for the treatment of MS. Our clinical and experimental studies have shown that the Bu Shen Yi Sui formula (BSYS) promotes axonal regeneration in MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, but the exact mechanism has not been thoroughly elucidated to date. In this study, we investigated the effects of BSYS and its two decomposed formulas-the Bu Shen formula (BS) and the Hua Tan Huo Xue formula (HTHX)-on brain-derived neurotrophic factor (BDNF)/TrkB and related signaling pathways to explore the mechanism by which axonal regeneration is promoted in vitro and in vivo. Damaged SH-SY5Y cells incubated with low serum were treated with BSYS-, BS-, and HTHX-containing serum, and EAE mice induced by the myelin oligodendrocyte glycoprotein (MOG)35-55 peptide were treated with BSYS. The results showed that the BSYS-containing serum markedly increased cell viability and increased the levels of growth associated protein (GAP)-43, phosphorylated (p)-cAMP-response element binding protein (CREB), BDNF, TrkB, and p-PI3K. ...Continue Reading

References

Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Louis F Reichardt
Apr 1, 2008·Journal of the Neurological Sciences·Tapas K MakarChristopher T Bever
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Sep 18, 2009·Journal of the Neurological Sciences·Lorenzo De SantiPlacido Bramanti
Dec 8, 2009·Experimental Neurology·Josephine HerzVolker Siffrin
Oct 27, 2011·Neurogenetics·M KlinkenbergM Jendrach
Nov 5, 2011·Journal of Cellular and Molecular Medicine·Wenjun ZhuMike Namaka
Mar 7, 2012·Cell and Tissue Research·Paul LingorMathias Bähr
Sep 3, 2013·Progress in Retinal and Eye Research·Satoru KatoKazuhiro Ogai
Dec 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Weidong PanHua Zhou
Sep 11, 2014·Neural Regeneration Research·Ling FangLei Wang
Feb 25, 2013·Neural Regeneration Research·Kangning LiLei Wang
Nov 29, 2014·CNS Neuroscience & Therapeutics·Pei-Cheng LiGao-Jun Teng
Feb 11, 2015·Neurological Research·Li Zhou, Yongping Fan
Mar 21, 2015·Fortschritte der Neurologie-Psychiatrie·A Salmen, A Chan
Mar 25, 2015·Advanced Biomedical Research·Shahnaz RazaviSayyed Hamid Zarkesh Esfahani
Aug 19, 2015·Frontiers in Molecular Neuroscience·Arsalan AlizadehSoheila Karimi-Abdolrezaee
Aug 28, 2015·International Journal of Molecular Medicine·Lirui ZhangHuilian Hou
Sep 9, 2015·Frontiers in Neurology·Jorge Correale, Mauricio F Farez
Dec 2, 2015·Neurodegenerative Disease Management·Jae Young LeeSteven Petratos
Dec 24, 2015·Frontiers in Neurology·Danielle E HarlowAugusto A Miravalle
Mar 11, 2016·Neurology·Ruth Ann MarrieUNKNOWN CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis
Apr 5, 2017·Cold Spring Harbor Perspectives in Biology·Aidong YuanRalph A Nixon
Sep 1, 2017·Journal of Neurophysiology·Ibis M Agosto-Marlin, Gordon S Mitchell
Sep 28, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Riley M Bove, Ari J Green

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Citations

Feb 6, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Juliana Ferreira VasquesAdriana da Cunha Faria-Melibeu

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