The budding yeast life cycle: More complex than anticipated?

Yeast
Gilles FischerBertrand Llorente

Abstract

The budding yeast, Saccharomyces cerevisiae, has served as a model for nearly a century to understand the principles of the eukaryotic life cycle. The canonical life cycle of S. cerevisiae comprises a regular alternation between haploid and diploid phases. Haploid gametes generated by sporulation are expected to quickly restore the diploid phase mainly through inbreeding via intratetrad mating or haploselfing, thereby promoting genome homozygotization. However, recent large population genomics data unveiled that heterozygosity and polyploidy are unexpectedly common. This raises the interesting paradox of a haplo-diplobiontic species being well-adapted to inbreeding and able to maintain high levels of heterozygosity and polyploidy, thereby suggesting an unanticipated complexity of the yeast life cycle. Here, we propose that unprogrammed mating type switching, heterothallism, reduced spore formation and viability, cell-cell fusion and dioecy could play key and uncharted contributions to generate and maintain heterozygosity through polyploidization.

References

May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J E HaberL B Rowe
Feb 3, 1999·Annual Review of Genetics·J E Haber
Jun 14, 2002·Proceedings. Biological Sciences·Duncan GreigMichael Travisano
Nov 16, 2005·The Journal of Cell Biology·Christof TaxisMichael Knop
Nov 24, 2005·Nature Reviews. Genetics·Luca Comai
Aug 8, 2006·Nature Genetics·Douglas M RuderferLeonid Kruglyak
Aug 25, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Knop
Sep 28, 2006·PLoS Genetics·Aleeza C GersteinSarah P Otto
Feb 6, 2007·Current Biology : CB·Max ReuterDuncan Greig
May 17, 2007·The New Phytologist·Z Jeffrey ChenDouglas Soltis
Nov 1, 2007·Biology Letters·Aleeza C GersteinSarah P Otto
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Isheng J TsaiVassiliki Koufopanou
Apr 17, 2008·Cell Cycle·Bertrand LlorenteLorraine S Symington
Feb 13, 2009·Nature·Gianni LitiEdward J Louis
May 14, 2010·PloS One·Helen A Murphy, Clifford W Zeyl
Jul 29, 2010·FEMS Yeast Research·Rim Al SafadiMichel Aigle
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amy C KellyReed B Wickner
Aug 27, 2014·Yeast·Zuzana Storchova
Mar 4, 2015·Nature·Anna M SelmeckiDavid Pellman
Sep 10, 2016·Cell·Brigida GalloneKevin J Verstrepen
Mar 6, 2018·Current Biology : CB·Yaniv HarariMartin Kupiec
Apr 13, 2018·Nature·Jackson PeterJoseph Schacherer
Jul 14, 2018·Nature Communications·Shou-Fu DuanFeng-Yan Bai
Oct 26, 2018·Molecular Biology of the Cell·Allison W McClureDaniel J Lew
Aug 10, 2019·Molecular Biology and Evolution·Lorenzo TattiniGianni Liti
Sep 13, 2019·Nature Communications·Guillaume CharronChristian R Landry

❮ Previous
Next ❯

Citations

Apr 9, 2021·Current Genetics·Laetitia Maroc, Cécile Fairhead
Jun 27, 2021·Microbial Biotechnology·Ramon Gonzalez, Pilar Morales
Nov 5, 2021·Genome Biology·Ioannis A PapaioannouMichael Knop
Nov 14, 2021·Nature Communications·Simone MozzachiodiGianni Liti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.