The burden of cholera in Uganda

PLoS Neglected Tropical Diseases
Godfrey BwireAnn Levin

Abstract

In 2010, the World Health Organization released a new cholera vaccine position paper, which recommended the use of cholera vaccines in high-risk endemic areas. However, there is a paucity of data on the burden of cholera in endemic countries. This article reviewed available cholera surveillance data from Uganda and assessed the sufficiency of these data to inform country-specific strategies for cholera vaccination. The Uganda Ministry of Health conducts cholera surveillance to guide cholera outbreak control activities. This includes reporting the number of cases based on a standardized clinical definition plus systematic laboratory testing of stool samples from suspected cases at the outset and conclusion of outbreaks. This retrospective study analyzes available data by district and by age to estimate incidence rates. Since surveillance activities focus on more severe hospitalized cases and deaths, a sensitivity analysis was conducted to estimate the number of non-severe cases and unrecognized deaths that may not have been captured. Cholera affected all ages, but the geographic distribution of the disease was very heterogeneous in Uganda. We estimated that an average of about 11,000 cholera cases occurred in Uganda each year, w...Continue Reading

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Citations

Jul 22, 2015·The American Journal of Tropical Medicine and Hygiene·Godfrey BwireChristopher Garimoi Orach
Apr 7, 2018·Journal of Environmental and Public Health·David MusokeDavid O Carpenter
Aug 8, 2018·Infection·Abraham Ajayi, Stella I Smith
Oct 9, 2014·The American Journal of Tropical Medicine and Hygiene·Christopher TroegerDennis L Chao
May 18, 2016·PLoS Neglected Tropical Diseases·Delphine SauvageotMartin A Mengel
Jun 16, 2019·Environmental Health and Preventive Medicine·Charles SsemugaboAbdullah Ali Halage
Sep 10, 2014·The American Journal of Tropical Medicine and Hygiene·Benjamin L NygrenEric D Mintz
Apr 3, 2020·International Health·Charles SsemugaboAbdullah Ali Halage

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