PMID: 3756127Sep 1, 1986Paper

The burden of genetically determined eye disease

The British Journal of Ophthalmology
J S GreenG J Johnson

Abstract

We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of total blindness and congenital defects for another 10-11%. Genetically determined conditions, diabetes, and senile macular degeneration (SMD) were the three leading causes of registration in each year, 1980-4. We calculated mean ages of registration and mean ages of death over the last four years for five major aetiological groups. Patients with genetic conditions were registered at a much younger age and had a correspondingly longer duration of blindness (21 years as compared with 5 years for either diabetes or SMD). Total 'person-years of blindness' was then calculated from the product of this duration of blindness and the total numbers registered in each group. This index shows that the overall individual and population impact of monogenic blindness is overwhelmingly greater than that of other causes (6849 person-years compared with 270 for diabetes and 430 for SMD). In view of this frequency and duration of monogenic blindness, and also of the substantial hereditary liability to relatively common causes of blindness such as glau...Continue Reading

References

May 1, 1975·American Journal of Ophthalmology·S A Baghdassarian, K F Tabbara
Apr 1, 1985·The British Journal of Ophthalmology·K F Tabbara, I A Badr

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Citations

Nov 17, 2006·International Ophthalmology·Sengul OzdekBerati Hasanreisoglu
Apr 3, 2002·Ophthalmology·Jerry VongphanitJie Jin Wang
Apr 20, 2006·The British Journal of Ophthalmology·S M Steidl
Jan 25, 2003·The British Journal of Ophthalmology·J A Montero, J M Ruiz-Moreno
Mar 9, 2010·Ophthalmology·Kengo HayashiManabu Mochizuki
Nov 14, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Mihai MititeluManjot K Gill
Apr 25, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Alexander M LevyRafael Grytz
Aug 1, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Rufino Silva
Aug 1, 1987·American Journal of Medical Genetics·J C BearG B Burke
Apr 1, 1992·Acta Ophthalmologica·T RosenbergR Riise
Jul 1, 1997·Developmental Medicine and Child Neurology·J S RahiA Foster
May 30, 2020·European Journal of Human Genetics : EJHG·Jane S GreenTerry-Lynn Young
Jan 1, 1988·Acta Ophthalmologica. Supplement·R Riise
Aug 15, 2019·Progress in Retinal and Eye Research·Craig BooteMichael J A Girard
May 19, 2021·Translational Vision Science & Technology·Mustapha El HamdaouiRafael Grytz

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