The burden of norovirus disease in children in the European Union

The Pediatric Infectious Disease Journal
Frank KowalzikFred Zepp

Abstract

Noroviruses (NoVs) are the leading cause of acute gastroenteritis across all age groups. Because a vaccine is in clinical development, burden of disease data are required to guide the eventual introduction of this vaccine. In this study, we estimate the burden of NoV disease in children less than 5 years of age in the European Union (EU). We carried out a literature search using PubMed to identify studies providing incidence or prevalence data for NoV disease in the EU. We applied the pooled average NoV incidence and prevalence rates to the EU population less than 5 years of age to obtain the annual number of NoV illnesses, medical visits, hospitalizations and deaths occurring in the EU among children younger than 5 years. Data from 12 studies were included. We estimate that NoV infection may cause up to 5.7 million illnesses in the community, 800,000 medical visits, 53,000 hospitalizations and 102 deaths every year in children younger than 5 years in the EU. The burden of NoV disease in children in the EU is substantial, and will grow in relative importance as rotavirus (RV) vaccines are rolled out in the EU. This burden of disease is comparable with the burden of RV disease in the EU before RV vaccine introduction. More count...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 3, 2001·American Journal of Epidemiology·M A de WitY T van Duynhoven
May 10, 2003·Emerging Infectious Diseases·Umesh D ParasharRoger I Glass
Oct 27, 2004·Emerging Infectious Diseases·Ben A LopmanJoyshri Sarangi
Aug 6, 2005·Journal of Clinical Microbiology·Bente OlesenPeter Gerner-Smidt
Jan 7, 2006·The Pediatric Infectious Disease Journal·Montse Soriano-GabarróThomas Verstraeten
Dec 21, 2006·Emerging Infectious Diseases·Alicia Sánchez-FauquierUNKNOWN Gegavi/VIGESS-Net Group
Aug 10, 2007·Epidemiology and Infection·S E MajowiczP N Sockett
Aug 6, 2008·Emerging Infectious Diseases·Manish M PatelUmesh D Parashar
Mar 26, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C KarstenH-I Huppertz
Jun 30, 2009·The Pediatric Infectious Disease Journal·Carolina Gutiérrez JunqueraAlicia Sánchez-Fauquier
Nov 5, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michaela SpackovaGerard Krause
Dec 4, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M LorrotD Gendrel
Apr 15, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Verena WiegeringHermann J Girschick
Jul 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I H M FriesemaY T H P van Duynhoven
Aug 19, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V Gonzalez-GalanJ Aznar-Martin
Nov 24, 2011·Human Vaccines·Catherine YenUmesh D Parashar
Dec 14, 2011·The New England Journal of Medicine·Robert L AtmarPaul M Mendelman
Jan 10, 2013·The Journal of Infectious Diseases·Paul A GastañaduyBenjamin A Lopman
Mar 22, 2013·The New England Journal of Medicine·Daniel C PayneUmesh D Parashar
Jul 16, 2013·Journal of Medical Virology·Carmen F MansoJesús L Romalde
Sep 12, 2013·PloS One·Claudio F LanataUNKNOWN Child Health Epidemiology Reference Group of the World Health Organization and UNICEF

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Citations

Mar 14, 2017·International Journal of Hygiene and Environmental Health·Karen E SettyJamie Bartram
Feb 28, 2017·Diagnostic Microbiology and Infectious Disease·Stijn JonckheereHans De Beenhouwer
Jun 22, 2017·The Journal of Infection·Hong-Lu ZhouXuan-Yi Wang
Feb 9, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marieke BierhoffAron J Hall
Aug 11, 2018·Expert Review of Vaccines·Claire P MattisonAron J Hall
Dec 23, 2020·Emerging Infectious Diseases·Martin Chi-Wai ChanUNKNOWN for NOROPATROL2
Feb 10, 2021·Journal of Medical Virology·Manar E Abdel-RahmanHadi M Yassine

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Methods Mentioned

BETA
PCR
enzyme linked immunosorbent assay

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