The Buzz about anabolic androgenic steroids: electrophysiological effects in excitable tissues.

Neuroendocrinology
Joseph G OberlanderLeslie P Henderson

Abstract

Anabolic androgenic steroids (AAS) comprise a large and growing class of synthetic androgens used clinically to promote tissue-building in individuals suffering from genetic disorders, injuries, and diseases. Despite these beneficial therapeutic applications, the predominant use of AAS is illicit: these steroids are self-administered to promote athletic performance and body image. Hand in hand with the desired anabolic actions of the AAS are untoward effects on the brain and behavior. While the signaling routes by which the AAS impose both beneficial and harmful actions may be quite diverse, key endpoints are likely to include ligand-gated and voltage-dependent ion channels that govern the activity of electrically excitable tissues. Here, we review the known effects of AAS on molecular targets that play critical roles in controlling electrical activity, with a specific focus on the effects of AAS on neurotransmission mediated by GABA(A) receptors in the central nervous system.

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A H Bass, S F Volman
Jan 1, 1967·The Journal of Endocrinology·R V Quincey, C H Gray
Sep 1, 1995·Trends in Pharmacological Sciences·J J LambertJ A Peters
Jan 1, 1995·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·D A MaloneR H Sample
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·L MartiniR Maggi
Mar 1, 1996·Trends in Neurosciences·M V Jones, G L Westbrook
Jan 1, 1997·Brain Research Bulletin·A E Herbison
Dec 22, 1999·Psychotherapy and Psychosomatics·A J Gruber, H G Pope
Mar 29, 2000·Hospital Medicine·A H MorrisW T Green
Jun 14, 2000·Animal Reproduction Science·C J ScottI J Clarke
Apr 25, 2001·Biology of Reproduction·A C Whitney, A S Clark
Nov 6, 2001·Medicine, Science, and the Law·S J MidgleyJ B Davies
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·S BasariaA S Dobs
Apr 3, 2002·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lori M IrvingMary Story
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·F CrestaniU Rudolph
Jan 25, 2003·Medicine and Science in Sports and Exercise·Tetsuro TamakiV Reggie Edgerton
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marisa RobertoGeorge R Siggins
Feb 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Andriana D PapaconstantinouKen M Brown
Jun 18, 2003·Pflügers Archiv : European journal of physiology·Aicha BouhlelClaude Léoty
Sep 25, 2003·Neuroscience and Biobehavioral Reviews·Ann S Clark, Leslie P Henderson
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Alvin M Matsumoto, William J Bremner
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marisa RobertoGeorge Robert Siggins
Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Graziano PinnaAlessandro Guidotti
Jun 30, 2005·CNS Drugs·Adam J Trenton, Glenn W Currier
Jul 12, 2005·Hormones and Behavior·Andrew H Bass, Harold H Zakon
Nov 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·B K YeeU Rudolph

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