The bZIP Proteins of Oncogenic Viruses.

Viruses
Madeleine L Stolz, Craig McCormick

Abstract

Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek's disease virus (MDV), Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate.

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Methods Mentioned

BETA
electrophoretic mobility shift
co-immunoprecipitation
cross-linking assay
ChIP
ChIP-seq
ubiquitination
affinity purification
pulldown
immunoprecipitation
acetylation

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