The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis.

Current Biology : CB
Christina LockwoodJeff Hardin

Abstract

The dramatic cell-shape changes necessary to form a multicellular organism require cell-cell junctions to be both pliable and strong. The zonula occludens (ZO) subfamily of membrane-associated guanylate kinases (MAGUKs) are scaffolding molecules thought to regulate cell-cell adhesion [1-3], but there is little known about their roles in vivo. To elucidate the functional role of ZO proteins in a living embryo, we have characterized the sole C. elegans ZO family member, ZOO-1. ZOO-1 localizes with the cadherin-catenin complex during development, and its junctional recruitment requires the transmembrane proteins HMR-1/E-cadherin and VAB-9/claudin, but surprisingly, not HMP-1/alpha-catenin or HMP-2/beta-catenin. zoo-1 knockdown results in lethality during elongation, resulting in the rupture of epidermal cell-cell junctions under stress and failure of epidermal sheet sealing at the ventral midline. Consistent with a role in recruiting actin to the junction in parallel to the cadherin-catenin complex, zoo-1 loss of function reduces the dynamic recruitment of actin to junctions and enhances the severity of actin filament defects in hypomorphic alleles of hmp-1 and hmp-2. These results show that ZOO-1 cooperates with the cadherin-cate...Continue Reading

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Citations

Feb 8, 2011·Antioxidants & Redox Signaling·Lorenza González-MariscalMonica Díaz-Coránguez
Nov 10, 2010·The Journal of Cell Biology·Ronen Zaidel-BarJeff Hardin
Oct 30, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Sima JonusaiteScott P Kelly
Sep 9, 2010·Current Opinion in Cell Biology·Huimin ZhangMichel Labouesse
Jun 23, 2009·Annals of the New York Academy of Sciences·Alan S Fanning, James M Anderson
Jul 15, 2015·Molecular Biology of the Cell·Sankar P ChakiGonzalo M Rivera
Jul 24, 2012·Current Opinion in Cell Biology·Timothy Loveless, Jeff Hardin
Mar 17, 2015·Developmental Biology·Stephen E Von Stetina, Susan E Mango
Apr 27, 2016·The Journal of Cell Biology·Jeff Hardin
Mar 19, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yi Dong, Jeffrey S Simske
Jun 30, 2016·Nature Reviews. Molecular Cell Biology·Ceniz ZihniMaria S Balda
Feb 10, 2017·ELife·Thanh Thi Kim Vuong-BrenderMichel Labouesse
Aug 11, 2018·Development·Eun Chan Park, Christopher Rongo
Apr 18, 2017·Annals of the New York Academy of Sciences·Lorenza González-MariscalFrancisco Cuellar-Perez
Feb 22, 2018·PloS One·Thanh Thi Kim Vuong-BrenderMichel Labouesse
Jun 20, 2020·Biochimica Et Biophysica Acta. Biomembranes·Florian RouaudSandra Citi
Jun 3, 2021·Journal of Developmental Biology·Luigy Cordova-BurgosMartha C Soto
Sep 18, 2021·Molecular and Cellular Biochemistry·Kamila Czubak-ProwizorMaria Swiatkowska

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