The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

Nature
B WasylykD Stehelin

Abstract

Cell transformation by oncogenes leads to changes in gene expression. A key event in this process seems to be activation of the transcription factors AP-1 and PEA 3. Their synergistic activities are required for efficient activation of transcription from different promoters by many different oncogenes, serum growth factors and the tumour promoter TPA. We show here that the products of the ets-1 and -2 proto-oncogenes, whose biological function was previously unknown, are transcription factors that activate transcription through the PEA 3 motif. The p68c-ets-1 protein specifically binds to DNA and contains a transcriptional activation domain. The ets-like gene family therefore seems to encode a new family of transcription factors, apparently unrelated to other transcription factors. The p68c-ets-1 protein cooperates with c-Fos and c-Jun (components of AP-1) for activation of transcription from the oncogene-responsive domain of the polyoma enhancer, indicating that combined activity of all three oncoproteins could be involved in the response of cells to growth stimuli.

References

Jan 1, 1989·Progress in Growth Factor Research·J L Imler, B Wasylyk
Apr 1, 1989·Trends in Genetics : TIG·P Herrlich, H Ponta
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M E MartinW R Folk
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D K WatsonT S Papas

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Citations

Mar 4, 1997·International Journal of Cancer. Journal International Du Cancer·J L BaertY de Launoit
Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Matrisian
Oct 1, 1994·Molecular Reproduction and Development·M J Tymms, I Kola
Oct 31, 2006·Journal of Cancer Research and Clinical Oncology·Eleftherios VairaktarisEfstratios Patsouris
Feb 20, 1993·Biochimica Et Biophysica Acta·R HromasM J Klemsz
Mar 1, 1992·The EMBO Journal·C CocquerelleB Bailleul
Jan 1, 1995·Brain Research. Molecular Brain Research·K SakimuraY Takahashi
Apr 1, 1995·Brain Research. Molecular Brain Research·M ButtiglioneG Gennarini
Jan 1, 1995·Biology of the Cell·T P CalmelsD Stéhelin
Dec 23, 1993·Biochimica Et Biophysica Acta·R Janknecht, A Nordheim
Dec 30, 1994·Biochimica Et Biophysica Acta·F Moreau-Gachelin
Jan 1, 1996·Free Radical Biology & Medicine·Y Sun, L W Oberley
Apr 1, 1994·Current Opinion in Immunology·J M Leiden, C B Thompson
Jun 1, 1991·Current Opinion in Cell Biology·J Ghysdael, M Yaniv
Dec 1, 1990·Current Opinion in Biotechnology·C M Steel
Jun 12, 2003·Gynecologic Oncology·Noriyuki TakaiIsao Miyakawa
May 1, 1997·Veterinary Immunology and Immunopathology·H Y YounA Hasegawa
Nov 22, 1996·Brain Research. Developmental Brain Research·F M Laurent-HuckJ M Felix
Apr 18, 1998·Biochimica Et Biophysica Acta·E JendraschakC von Schacky
Dec 12, 1997·Biochimica Et Biophysica Acta·A Minden, M Karin

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