The C-terminal domain of Sin1 interacts with the SWI-SNF complex in yeast.

Molecular and Cellular Biology
J Pérez-Martín, A D Johnson

Abstract

In the yeast Saccharomyces cerevisiae, the SWI-SNF complex has been proposed to antagonize the repressive effects of chromatin by disrupting nucleosomes. The SIN genes were identified as suppressors of defects in the SWI-SNF complex, and the SIN1 gene encodes an HMG1-like protein that has been proposed to be a component of chromatin. Specific mutations (sin mutations) in both histone H3 and H4 genes produce the same phenotypic effects as do mutations in the SIN1 gene. In this study, we demonstrate that Sin1 and the H3 and H4 histones interact genetically and that the C terminus of Sin1 physically associates with components of the SWI-SNF complex. In addition, we demonstrate that this interaction is blocked in the full-length Sin1 protein by the N-terminal half of the protein. Based on these and additional results, we propose that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome.

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Citations

Jul 11, 2014·Molecular Aspects of Medicine·Rui KangDaolin Tang
Jun 9, 2015·Trends in Genetics : TIG·Malcolm WhitewayRoberto Rodríguez-Ortiz
May 14, 1999·Current Opinion in Genetics & Development·S Jacobson, L Pillus
Dec 6, 2008·PLoS Genetics·Nilabja SikdarKyungjae Myung
Jun 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gitit HershkovitsDon J Katcoff
Nov 26, 2004·The Journal of Biological Chemistry·Minna NovoselerDon J Katcoff
Feb 26, 2019·The Journal of Biological Chemistry·Anthony RösslMichael Downey
Sep 27, 2006·Molecular and Cellular Biology·Silvia Jimeno-GonzálezSebastián Chávez
Jul 26, 2002·Molecular and Cellular Biology·Zhi-Kai ZhangGanjam V Kalpana
Jul 28, 1999·FEMS Microbiology Reviews·J Pérez-Martín
Nov 5, 2020·Epigenetics & Chromatin·Sarah M Innis, Birgit Cabot
Jul 25, 2000·Trends in Genetics : TIG·P Sudarsanam, F Winston

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