PMID: 9545622Apr 18, 1998Paper

The C-terminal fragment of big endothelin-1 does not potentiate the vasoactive effects of endothelin-1

Clinical Physiology
A Ottosson-SeebergerG Ahlborg

Abstract

The aim was to study the cardiovascular effects of the C-terminal (22-38) fragment of big endothelin-1, which is produced by the cleavage of big endothelin-1 (big ET-1) to endothelin-1 (ET-1). An intravenous infusion of the (22-38) fragment (4, 8 and 12 pmol kg-1 min-1, each dose for 10 min) was given to 10 healthy subjects. Four control subjects received 0.9% saline. Two additional subjects received ET-1 1 (0.2 and 4 pmol kg-1 min-1, each dose for 20 min) alone or combined with an equimolar infusion of the (22-38) fragment on two separate occasions. The fragment infusion did not alter heart rate, mean arterial blood pressure, cardiac output, systemic or pulmonary vascular resistance, splanchnic, cerebral or forearm blood flow. Renal blood flow showed a slight fall (11%, P < 0.001) in the fragment group of the same magnitude as in a previous control study. After the fragment infusion, a decrease in mean pulmonary arterial pressure (MPAP) by 12% (P < 0.01) and in pulmonary capillary wedge pressure (PCWP) by 31% (P < 0.001) was noted, which did not differ from the pulmonary pressures in the saline-infused control group. The (22-38) fragment, when combined with ET-1, was not able to modify the effects of ET-1 on heart rate, mean a...Continue Reading

References

Mar 1, 1991·Acta Physiologica Scandinavica·A HemsénJ M Lundberg
Nov 14, 1991·Biochemical and Biophysical Research Communications·E WeitzbergJ M Lundberg
Aug 21, 1990·European Journal of Pharmacology·Y MatsumuraS Morimoto
Oct 30, 1990·Biochemical and Biophysical Research Communications·T FukurodaM Yano
Jun 1, 1996·Journal of Applied Physiology·G AhlborgJ M Lundberg

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Citations

Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C LöwbeerA Gutierrez

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