The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

Proceedings of the National Academy of Sciences of the United States of America
O Rozenblatt-RosenE Canaani

Abstract

The ALL-1 gene was discovered by virtue of its involvement in human acute leukemia. Its Drosophila homolog trithorax (trx) is a member of the trx-Polycomb gene family, which maintains correct spatial expression of the Antennapedia and bithorax complexes during embryogenesis. The C-terminal SET domain of ALL-1 and TRITHORAX (TRX) is a 150-aa motif, highly conserved during evolution. We performed yeast two hybrid screening of Drosophila cDNA library and detected interaction between a TRX polypeptide spanning SET and the SNR1 protein. SNR1 is a product of snr1, which is classified as a trx group gene. We found parallel interaction in yeast between the SET domain of ALL-1 and the human homolog of SNR1, INI1 (hSNF5). These results were confirmed by in vitro binding studies and by demonstrating coimmunoprecipitation of the proteins from cultured cells and/or transgenic flies. Epitope-tagged SNR1 was detected at discrete sites on larval salivary gland polytene chromosomes, and these sites colocalized with around one-half of TRX binding sites. Because SNR1 and INI1 are constituents of the SWI/SNF complex, which acts to remodel chromatin and consequently to activate transcription, the interactions we observed suggest a mechanism by whic...Continue Reading

References

Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R Paro, D S Hogness
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M MazoI B Dawid
Feb 15, 1995·JAMA : the Journal of the American Medical Association·S A SchichmanC M Croce
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·B R CairnsR D Kornberg
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·C L PetersonM P Scott
Apr 15, 1996·Genes & Development·R E KingstonA N Imbalzano
Apr 1, 1996·Current Opinion in Genetics & Development·C L Peterson
Nov 1, 1996·Genetics·A MochizukiY Iwasa
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·D TroucheT Kouzarides

❮ Previous
Next ❯

Citations

Dec 7, 2000·Genes, Chromosomes & Cancer·N R dos SantosA G van Kessel
Aug 31, 2001·Journal of Cellular Biochemistry·S ChakrabortyG Nucifora
May 29, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Keiichi SakaiTakanori Hirose
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Charlotte GrimaudGiacomo Cavalli
Dec 21, 2000·Current Oncology Reports·A JakubowiakS D Nimer
Feb 13, 2008·International Journal of Hematology·Yu-Chieh SuDian-Kun Li
May 21, 2005·Biochemical and Biophysical Research Communications·Kazunori ShibuyaNobuyoshi Shimizu
Jan 10, 2002·Biochimica Et Biophysica Acta·I Muyrers-Chen, R Paro
Jun 1, 2002·Gene·Raul Alvarez-Venegas, Zoya Avramova
Oct 31, 2003·Gene·Raffaella CinquettiGiovanni Bernardini
Aug 2, 2002·Trends in Biochemical Sciences·Robert SchneiderTony Kouzarides
Sep 12, 2002·Trends in Molecular Medicine·Emma C Collins, Terence H Rabbitts
Jun 5, 2001·Nature Reviews. Molecular Cell Biology·N J Francis, R E Kingston
Feb 18, 2004·Nature Reviews. Cancer·Charles W M Roberts, Stuart H Orkin
Aug 22, 2002·Nature Reviews. Cancer·Shi Huang
May 19, 2006·Nature Reviews. Genetics·Ivana L de la SernaAnthony N Imbalzano
Nov 15, 2011·Nature Structural & Molecular Biology·Kwang Won JeongMichael R Stallcup
Sep 1, 1999·British Journal of Haematology·J F Dimartino, M L Cleary
Aug 16, 2002·British Journal of Haematology·Louise K Jones, Vaskar Saha
Apr 26, 2002·Neuropathology and Applied Neurobiology·J A KrausT Pietsch
Sep 11, 2010·The Journal of Biological Chemistry·Brian R Keppler, Trevor K Archer
Apr 29, 2009·The Journal of Biological Chemistry·Supratik DasGanjam V Kalpana
Dec 3, 2005·The Cerebellum·Emmanuelle Bitoun, Kay Elizabeth Davies
Sep 19, 2001·Current Opinion in Hematology·D Liedman, N Zeleznik-Le
Jun 4, 2002·Current Opinion in Hematology·Patricia ErnstStanley J Korsmeyer
Jul 5, 2006·Genes & Development·Scott J BultmanTerry Magnuson
Sep 7, 2001·Genes & Development·K R KatsaniC P Verrijzer
Aug 5, 2004·European Journal of Clinical Investigation·G Mitterbauer-Hohendanner, C Mannhalter
Mar 25, 2000·Molecular and Cellular Biology·I L de La SernaA N Imbalzano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.