The C-Type Lectin Domain Gene Family in Aedes aegypti and Their Role in Arbovirus Infection.

Viruses
Zach N Adelman, Kevin M Myles

Abstract

Several medically important flaviviruses that are transmitted by mosquitoes have been shown to bind to the C-type lectin fold that is present in either vertebrate or invertebrate proteins. While in some cases this interaction is part of a neutralizing anti-viral immune response, many reports have implicated this as critical for successful virus entry. Despite the establishment of mosquito C-type lectin domain containing proteins (CTLDcps) as known host factors in assisting the infectious process for flaviviruses, little is known about the structural characteristics of these proteins and their relationships to each other. In this report, we describe the manual annotation and structural characterization of 52 Aedes aegypti CTLDcps. Using existing RNAseq data, we establish that these genes can be subdivided into two classes: those highly conserved with expression primarily in development (embryo/early larvae) and those with no clear orthologs with expression primarily in late larvae/pupae or adults. The latter group contained all CTLDcps that are regulated by the Toll/Imd immune pathways, all known microbiome-regulating CTLDcps, and almost all CTLDcps that are implicated as flavivirus host factors in A. aegypti. Finally, we attemp...Continue Reading

References

Jul 31, 1998·Bioinformatics·A A SalamovM B Swindells
Oct 5, 2002·Science·Robert A HoltStephen L Hoffman
Apr 12, 2003·The Journal of Experimental Medicine·Boonrat TassaneetrithepMary A Marovich
Mar 27, 2004·Science·Mike A OstaFotis C Kafatos
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant
Dec 13, 2005·The FEBS Journal·Alex N Zelensky, Jill E Gready
May 8, 2007·Nucleic Acids Research·Lukas KällErik L L Sonnhammer
Jun 26, 2007·Science·Robert M WaterhouseGeorge K Christophides
Jul 8, 2008·PLoS Pathogens·Zhiyong XiGeorge Dimopoulos
Apr 22, 2009·The Journal of Biological Chemistry·Anna K D SchnitgerMike A Osta
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jayme A Souza-NetoGeorge Dimopoulos
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
Jul 16, 2011·EMBO Reports·Sang Woon ShinAlexander S Raikhel
Oct 1, 2011·Nature Methods·Thomas Nordahl PetersenHenrik Nielsen
Dec 15, 2011·MBio·Panisadee AvirutnanMichael S Diamond
Sep 5, 2013·Genome Biology·Eduardo LeeSuzanna E Lewis
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jul 19, 2015·Developmental and Comparative Immunology·Xiang-Jun RaoXiao-Qiang Yu
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Guang ChenAnthony A James
Mar 22, 2016·PloS One·José M C RibeiroEric Calvo
May 14, 2016·Nature Microbiology·Xiaojing PangGong Cheng
Aug 31, 2016·Nature Microbiology·Xiaojing PangGong Cheng

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Citations

Nov 19, 2019·Viral Immunology·Manuel Castillo-Méndez, Verónica Valverde-Garduño
Aug 2, 2018·Viruses·Michelle L Flenniken
Jan 7, 2021·Open Biology·B M C Randika Wimalasiri-YapaFrancesca D Frentiu
Jul 2, 2020·ACS Infectious Diseases·Alexander S GoldTonya M Colpitts
Aug 24, 2021·Developmental and Comparative Immunology·Yu-Hsun HuangHan-Ching Wang

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Datasets Mentioned

BETA
AAEL011616
AAEL014385
but
AAEL018265
AAEL022823
AAEL026955
AAEL014382
AAEL012353

Methods Mentioned

BETA
RNAseq

Software Mentioned

Webapollo
RNAseq
BedTools
SP
SignalP
BLAST
Illustrator for Biological Sequences
MEGA6
Search
Muscle

Related Concepts