The C-type lectin macrophage galactose-type lectin impedes migration of immature APCs

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sandra J van VlietYvette van Kooyk

Abstract

Dendritic cells (DCs) are the most potent APCs of the immune system that seed the peripheral tissues and lymphoid organs. In an immature state, DCs sample their surroundings for incoming pathogens. Upon Ag encounter, DCs mature and migrate to the lymph node to induce adaptive immune responses. The C-type macrophage galactose-type lectin (MGL), expressed in immature DCs, mediates binding to glycoproteins carrying GalNAc moieties. In the present study, we demonstrate that MGL ligands are present on the sinusoidal and lymphatic endothelium of lymph node and thymus, respectively. MGL binding strongly correlated with the expression of the preferred MGL ligand, alpha-GalNAc-containing glycan structures, as visualized by staining with the alpha-GalNAc-specific snail lectin Helix pomatia agglutinin. MGL(+) cells were localized in close proximity of the endothelial structures that express the MGL ligand. Strikingly, instead of inducing migration, MGL mediated retention of human immature DCs, as blockade of MGL interactions enhanced DC trafficking and migration. Thus, MGL(+) DCs are hampered in their migratory responses and only upon maturation, when MGL expression is abolished; these DCs will be released from their MGL-mediated restraints.

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Citations

Jan 22, 2013·Annual Review of Immunology·Gianna Elena Hammer, Averil Ma
Jul 7, 2015·Biomaterials Science·N A HotalingJ E Babensee
May 7, 2016·Biomolecules·Lenneke A M Cornelissen, Sandra J Van Vliet
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Feb 4, 2016·Journal of Immunology Research·Ilaria Grazia ZizzariAurelia Rughetti
Feb 26, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher N JondleJyotika Sharma
Aug 1, 2020·Frontiers in Cellular and Infection Microbiology·Malgorzata E MnichNina M van Sorge
Jul 15, 2009·Immunological Reviews·Juan J García-Vallejo, Yvette van Kooyk
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sophie A DusoswaJuan J Garcia-Vallejo
Nov 22, 2011·PLoS Pathogens·Thierry FontaineJean-Paul Latgé
Apr 26, 2012·European Journal of Immunology·Chiara NapoletanoMarianna Nuti
Mar 9, 2021·Frontiers in Immunology·Charlotte CastenmillerYvette van Kooyk

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