Jun 7, 2006

The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
John J LimaRobert Wise


Our goal was to explore associations between ss2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively (p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

  • References23
  • Citations12


Mentioned in this Paper

European Continental Ancestry Group
African American
Adrenergic Receptor
NEUROD1 wt Allele
Genetic Polymorphism
Beta-2 Adrenergic Receptors
Single Nucleotide Polymorphism

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