The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs

Molecular Biology of the Cell
Morgan TuckerMin Han

Abstract

The homeobox-containing aristaless-related protein ARX has been directly linked to the development of a number of human disorders involving mental retardation and epilepsy and clearly plays a critical role in development of the vertebrate central nervous system. In this work, we investigate the role of ALR-1, the Caenorhabditis elegans aristaless orthologue, in amphid sensory function. Our studies indicate that ALR-1 is required for maintenance of the amphid organ structure throughout larval development. Mutant analysis indicates a progressive loss in the amphid neurons' ability to fill with lipophilic dyes as well as a declining chemotactic response. The degeneration in amphid function corresponds with a failure of the glial-like amphid socket cell to maintain its specific cell shape and cell-cell contacts. Consistent with ALR-1 expression within the amphid socket cell, our results indicate a cell autonomous role for ALR-1 in maintaining cell shape. Furthermore, we demonstrate a role for ALR-1 in the proper morphogenesis of the anterior hypodermis. Genetic interaction tests also suggest that ALR-1 may function cooperatively with the cell adhesion processes in maintaining the amphid sensory organs.

References

Apr 1, 1977·The Journal of Comparative Neurology·J A Lewis, J A Hodgkin
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·C I BargmannH R Horvitz
Jul 25, 1990·Nucleic Acids Research·A FireR Waterston
Oct 1, 1986·Developmental Biology·L A PerkinsJ G Culotti
May 1, 1974·Genetics·S Brenner
Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
May 20, 1981·The Journal of Comparative Neurology·P S AlbertD L Riddle
Feb 11, 1994·Science·M ChalfieD C Prasher
Mar 18, 1999·Development Genes and Evolution·B GalliotD Miller
Oct 6, 1999·Current Opinion in Cell Biology·U Tepass
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G Shemer, B Podbilewicz
May 15, 2002·Current Biology : CB·Massimo A HilliardPaolo Bazzicalupo
Jun 21, 2002·Methods in Enzymology·Kent McDonald, Thomas Müller-Reichert
Oct 3, 2002·Molecular Genetics and Metabolism·R OhiraE R B McCabe
Mar 11, 2003·Annual Review of Neuroscience·Oscar Marín, John L R Rubenstein
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Margaret J Wheelock, Keith R Johnson
Feb 3, 2004·TheScientificWorldJournal·A J Piekny, P E Mains
Mar 3, 2004·Brain Research. Molecular Brain Research·Karine PoirierJamel Chelly

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Citations

Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Irini TopalidouMartin Chalfie
Nov 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Irini Topalidou, Martin Chalfie
Apr 18, 2012·Genome Research·John Isaac MurrayRobert H Waterston
Jul 7, 2011·Glia·Grigorios Oikonomou, Shai Shaham
Jan 23, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Karolina Mizeracka, Maxwell G Heiman
Jul 23, 2020·Journal of Neurogenetics·Wendy FungMaxwell G Heiman
Feb 12, 2021·The FEBS Journal·Albert Zhang, Dong Yan

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