The calcineurin activity and MCIP1.4 mRNA levels are increased by innervation in regenerating soleus muscle

Biochemical and Biophysical Research Communications
Rita FenyvesiE Zádor

Abstract

The level of active subunit of calcineurin and the calcineurin (Cn) enzyme activity are increased in innervated but not in denervated slow type regenerating skeletal soleus muscle. These nerve-dependent increases were not accompanied by similar increases in the mRNA levels. The changes in the mRNA level of the modulatory calcineurin interacting protein, MCIP1.4, reflected the calcineurin activity and did not increase in denervated regenerating muscles compared to the innervated regenerating controls. The increases in Cn activity and in MCIP1.4 mRNA levels occurred before the switch from fast to slow-type myosin heavy chain isoforms, a phenomenon similarly known to be dependent on innervation. This highlights the role of mediators, acting between the nerve and calcineurin, in the formation of slow fiber identity.

References

Jun 1, 1989·Journal of Muscle Research and Cell Motility·S SchiaffinoT Lømo
Feb 1, 1997·Cell Structure and Function·R JerkovicS Schiaffino
Mar 9, 2000·Nature Cell Biology·M MurgiaS Schiaffino
Apr 12, 2000·European Journal of Biochemistry·D SommerP M Stemmer
Apr 25, 2000·The Journal of Biological Chemistry·X BigardR Ventura-Clapier
Jun 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E N Olson, R S Williams
Sep 26, 2000·American Journal of Physiology. Cell Physiology·S J SwoapS C Kandarian
Oct 16, 2001·American Journal of Physiology. Cell Physiology·A X BigardR Ventura-Clapier
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A L SerranoS Schiaffino
Sep 5, 2002·Muscle & Nerve·Hui ZhongV Reggie Edgerton
Nov 30, 2002·Trends in Pharmacological Sciences·Stefano Schiaffino, AntonioL Serrano
Jan 30, 2003·Trends in Cardiovascular Medicine·Beverly A RothermelR Sanders Williams
May 30, 2003·American Journal of Physiology. Cell Physiology·Erno Zádor, Frank Wuytack
May 30, 2003·Molecular and Cellular Biology·Stephanie A ParsonsJeffery D Molkentin
Nov 19, 2003·Biochemical and Biophysical Research Communications·Rhonda Bassel-Duby, Eric N Olson

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Citations

Jun 30, 2005·Acta Neuropathologica·Kunihiro SakumaMasahiro Yasuhara
Dec 2, 2010·Histochemistry and Cell Biology·Erno ZádorFrank Wuytack
Mar 4, 2005·Clinical and Experimental Pharmacology & Physiology·Masataka SuwaShuzo Kumagai
Aug 6, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·András SzabóErno Zádor
Mar 24, 2005·PLoS Medicine·R Sanders Williams, William E Kraus
Feb 17, 2015·International Journal of Molecular Sciences·Xiaoling ChenRuinan Zhang
Aug 19, 2008·Biochemical and Biophysical Research Communications·Erno Zádor
Apr 3, 2010·Biochimica Et Biophysica Acta·Tiffany K Roberts-WilsonS Russ Price
Apr 23, 2016·Muscle & Nerve·Nathalie KoulmannSébastien Banzet
Nov 15, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Karin EizemaMaria E Everts
Apr 12, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alexei VázquezAlbert-László Barabási
Jan 21, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thierry LaunayOnnik Agbulut

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