PMID: 6400754May 1, 1983Paper

The calcium channel blockers: pharmacology and clinical applications

Canadian Anaesthetists' Society Journal
H F Mizgala

Abstract

The calcium channel blockers provide an exciting and effective new therapeutic tool in the management of ischaemic cardiac syndromes and may prove popular and effective in the treatment of a variety of other disorders. They have provided a new approach to treatment and have added new insights into the pathogenesis of ischaemic cardiac syndromes. Their introduction into clinical practice has been swift and many of our concepts regarding their pharmacologic activities in man remain based on theoretic considerations. Their expanding clinical use and further comparative studies will undoubtedly provide further information in regard to indications, adverse effects, drug interaction and long-term safety. Particular caution is advised when they are combined with certain antiarrhythmic agents, digitalis and particularly beta adrenergic blocking agents. Little is known about their interaction with various general anaesthetic agents and for this reason particular vigilance is required as more patients receiving these agents are admitted for surgical procedures.

References

May 1, 1982·Annals of Internal Medicine·D R Rosing, S E Epstein
Dec 1, 1980·The American Journal of Cardiology·P D Henry
Dec 23, 1982·The New England Journal of Medicine·E Braunwald
Oct 1, 1982·The American Journal of Cardiology·H O Klein, E Kaplinsky
Oct 1, 1982·The American Journal of Cardiology·M PackerV B Subramanian
Jan 9, 1982·British Medical Journal·R H Robson, M C Vishwanath
Oct 1, 1982·The American Journal of Cardiology·V B SubramanianE B Raftery
Oct 1, 1981·Anesthesiology·C LynchN Sperelakis

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Citations

Jan 1, 1989·Journal of Family History·J H Moore, G R Campbell

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