The calcium pump of the endoplasmic reticulum plays a role in midline signaling during early zebrafish development

Brain Research. Developmental Brain Research
Robbert Creton

Abstract

During early vertebrate development, a signaling network is activated along the midline of the embryo. This signaling network induces the neural tube floor plate and ventral brain regions. In turn, induction of the ventral brain region is important for bilateral division of the forebrain and bilateral separation of the eyes. The present study provides direct evidence for a role of the endoplasmic reticulum Ca(2+) pump in zebrafish midline signaling. The endoplasmic reticulum Ca(2+) pump was inhibited in zebrafish embryos using thapsigargin or cyclopiazonic acid. Inhibition of the endoplasmic reticulum Ca(2+) pump during early gastrulation induces cyclopia, mimicking defects observed in cyclops, squint, one-eyed pinhead, and silberblick mutant embryos. In contrast, inhibition of the endoplasmic reticulum Ca(2+) pump during mid-gastrulation does not induce cyclopia, but does induce tail defects, mimicking defects observed in no-tail mutant embryos. This study is the first to relate thapsigargin and cyclopiazonic acid with induction of cyclopia. In addition, obtained results provide new information on the roles of Ca(2+) in embryonic development and may lead to new insights on the mechanisms underlying holoprosencephaly, a relativ...Continue Reading

References

Jul 1, 1995·Developmental Biology·E ReinhardT Meyer
Oct 1, 1994·The Biological Bulletin·C L Meng, D C Chang
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Feb 1, 1997·Developmental Biology·D C SlusarskiR T Moon
Apr 1, 1997·Developmental Biology·C P Heisenberg, C Nüsslein-Volhard
Jul 15, 1997·Developmental Biology·M E HalpernC B Kimmel
Jun 5, 1998·Trends in Pharmacological Sciences·M TreimanS B Christensen
Jun 25, 1998·Development, Growth & Differentiation·C F LeungA L Miller
Aug 29, 1998·The Journal of Cell Biology·L M JohnP Camacho
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GillandS E Webb
Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L F Jaffe
Sep 24, 1999·Developmental Biology·K W LeeA L Miller
Sep 30, 1999·Microscopy Research and Technique·S A Stricker, M Whitaker
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S E Webb, A L Miller
Mar 21, 2000·Genesis : the Journal of Genetics and Development·A L RubinsteinM E Halpern
Apr 18, 2000·Human Molecular Genetics·P Blader, U Strähle
May 18, 2000·Microscopy Research and Technique·D C Chang, P Lu
Jun 1, 2000·Development, Growth & Differentiation·C F LeungA L Miller
Jun 20, 2000·Trends in Genetics : TIG·M KühlR T Moon
Aug 3, 2000·Human Mutation·D Wallis, M Muenke
Sep 26, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B Appel
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
May 23, 2001·Current Biology : CB·J B WallingfordS E Fraser
Jun 1, 2001·Nature·Y Chen, A F Schier
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Jul 31, 2001·Genesis : the Journal of Genetics and Development·S BinghamA Chandrasekhar
Aug 17, 2001·Brain Research. Developmental Brain Research·R AshworthS R Bolsover
Aug 27, 2002·Current Biology : CB·Martin D BootmanH Llewelyn Roderick
Oct 3, 2002·Journal of Cell Science·Joerg Huelsken, Juergen Behrens
Jan 10, 2003·Nucleic Acids Research·Judy SpragueMonte Westerfield
Jun 28, 2003·Zygote : the Biology of Gametes and Early Embryos·Sarah E Webb, Andrew L Miller
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah E Webb, Andrew L Miller
Jul 23, 2003·Developmental Biology·Trudi A WestfallDiane C Slusarski
Sep 4, 2003·The Journal of Cell Biology·Trudi A WestfallDiane C Slusarski

❮ Previous
Next ❯

Citations

Jun 26, 2008·Environmental Science and Pollution Research International·Stefan ScholzDoris Voelker
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·A M EbertD M Garrity
Dec 15, 2015·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Coco de KoningHarry Emmen
Sep 28, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kirsten Henn, Thomas Braunbeck
Nov 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sarah C RothschildRobert M Tombes
Sep 28, 2010·Stem Cells·Hsuan-Hwai LinYuh-Man Sun
Apr 26, 2016·Journal of Applied Toxicology : JAT·Juyoung ShimJulie A Gosse
Oct 2, 2012·Stem Cells International·Julieta Aprea, Federico Calegari
Jun 15, 2014·Regulatory Toxicology and Pharmacology : RTP·Stefan ScholzMarc Léonard
Jul 5, 2005·Developmental Cell·Bhaskarjyoti SarmahSusan R Wente
Jun 12, 2016·Toxicology and Applied Pharmacology·Lambert BodeweinMartina Fenske
Jul 1, 2016·Chemical Research in Toxicology·Luís M FélixAna M Coimbra
Aug 15, 2017·Nanomedicine·Carmen Teijeiro-ValiñoLaura Sánchez
Jan 24, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yang LiuXizeng Feng
Oct 18, 2012·Metallomics : Integrated Biometal Science·Ignacio E LeónSusana B Etcheverry
Dec 16, 2006·The Journal of Biological Chemistry·Niclas W SchifferBettina Schmid
Nov 2, 2018·International Journal of Molecular Sciences·Sudip PaudelMargaret Saha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.