PMID: 13563804Jul 20, 1958Paper

The calculation of transfer rates in two compartment systems not in dynamic equilibrium

The Journal of General Physiology
E Y BERGER, J M STEELE

Abstract

Dynamic equilibrium in a biological system implies that the compartment under study does not change in size during the period of observation. In many biological systems there are, however, net changes with time and this report deals with the mathematical treatment necessary to calculate unequal rates of inflow and outflow. A method is presented for the calculation of transfer rates in a two compartment system when the rates of flow between these compartments are unequal but constant. Equations were developed to calculate the amount of material transported per unit time derived from measurements of specific activity and compartment size. The problems of (1) sampling from the pool and (2) the effects of analytical errors on the estimation of rate have been evaluated. An example has been presented in which the derived equations have been applied to a study of the simultaneous passage of sodium into and out of a permanently isolated loop of bowel.

References

May 1, 1951·The Journal of General Physiology·C W SHEPPARD, G E BEYL

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Citations

Jan 1, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·G NellW Rummel
Mar 1, 1970·The American Journal of Digestive Diseases·A Righetti, R Levitan
Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·O GrishinaM Descroix-Vagne
Dec 1, 1968·The Journal of General Physiology·E Y BergerG Kanzaki
Aug 1, 1974·The Journal of Clinical Investigation·T F ParkerJ S Fordtran
Apr 1, 1976·The Journal of Clinical Investigation·P Vergne-MariniJ S Fordtran
Dec 1, 1980·The Journal of Clinical Investigation·G R DavisJ S Fordtran
Jun 1, 1981·The Journal of Clinical Investigation·G R DavisJ S Fordtran
Feb 1, 1984·British Journal of Pharmacology·D Mailman
Apr 1, 1980·British Journal of Pharmacology·D Mailman
Dec 21, 1981·Journal of Theoretical Biology·D Winne
Jan 11, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cole B EnnsMatthew E Loewen
May 10, 1963·Annals of the New York Academy of Sciences·E Y BERGER
Jan 1, 1960·Archives internationales de physiologie et de biochimie·E SCHOFFENIELS
May 1, 1961·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·B E VAUGHAN, E L ALPEN
Nov 1, 1985·Gastroenterology·J S FordtranC A Santa Ana

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