The cAMP signal transduction pathway mediates resistance to dicarboximide and aromatic hydrocarbon fungicides in Ustilago maydis

Fungal Genetics and Biology : FG & B
M A RameshJames W Kronstad

Abstract

The cAMP signal transduction pathway mediates the switch between yeast-like and filamentous growth and influences both sexual development and pathogenicity in the smut fungus Ustilago maydis. Signaling via cAMP may also play a role in fungicide resistance in U. maydis. In particular, the adr1 gene, which encodes the catalytic subunit of the U. maydis cAMP-dependent protein kinase (PKA), is implicated in resistance to the dicarboximide and aromatic hydrocarbon fungicides. In this study, we examined the sensitivity of PKA to vinclozolin and could not demonstrate direct inhibition of protein kinase activity. However, we did find that mutants with disruptions in the ubc1 gene, which encodes the regulatory subunit of PKA, were resistant to both vinclozolin and chloroneb. We also found that these fungicides altered the morphology of both wild-type and ubc1 mutant cells. In addition, strains that are defective in ubc1 display osmotic sensitivity, a property often associated with vinclozolin and chloroneb resistance in other fungi.

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Citations

Apr 20, 2006·Current Genetics·Márcia Eliana da Silva FerreiraGustavo H Goldman
Jan 26, 2011·Molecular Plant-microbe Interactions : MPMI·Hye-Seon KimSeogchan Kang
Mar 26, 2003·Annual Review of Phytopathology·Nancy LeeJames W Kronstad
Sep 18, 2002·Pest Management Science·Pierre LerouxFlorence Chapeland
Sep 3, 2004·Molecular Microbiology·Kaihei KojimaTetsuro Okuno
Aug 11, 2006·Pest Management Science·Zhonghua MaThemis Michailides

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