The cancer anorexia-cachexia syndrome: myth or reality?

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Wael Lasheen, Declan Walsh

Abstract

Controversy exists as what constitutes the cancer anorexia-cachexia syndrome (CACS), and whether it truly is a distinct clinical disorder. In this study, we aimed to: (1) assess if CACS is a distinct clinical disorder, (2) identify the symptoms characteristic of CACS, (3) evaluate CACS impact on patient outcomes (symptom burden and survival time from referral). Consecutive patients referred to palliative medicine were assessed by 38-symptom questionnaire. Demographics, Eastern Cooperative Oncology Group (ECOG), disease and extent, and survival were recorded. CACS, defined as anorexia plus weight loss (>10% of pre-illness weight). For analysis, patients were divided into four groups: (1) group CACS; (2) group A (only anorexia, NO >10% pre-illness weight loss); (3) group WL (weight loss >10% pre-illness weight only but NO anorexia); and (4) group N (NO weight loss >10% pre-illness weight and NO anorexia). Symptoms present in > or =5%, and patients with complete data were analyzed. Four hundred eighty-four patients had complete data, metastatic cancer, and 26 symptoms present in > or =5%. Groups had significantly different ECOG, symptom burden, and survival. Significantly different symptom prevalence between groups: dry mouth,*ear...Continue Reading

References

Jan 1, 1977·JPEN. Journal of Parenteral and Enteral Nutrition·G L BlackburnM F Smith
Oct 1, 1992·American Journal of Clinical Oncology·J FeliuJ M Montero
Jan 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R FietkauR Sauer
Sep 2, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E BrueraJ Hanson
May 2, 2000·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·D WalshL Rybicki
Jun 13, 2001·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J M RibaudoW T Leslie
Jun 10, 2006·The American Journal of Clinical Nutrition·Kenneth C FearonUNKNOWN Cancer Cachexia Study Group
Apr 9, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Paul GlareAntonio Vigano
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Dec 26, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Federico Bozzetti, Luigi Mariani

❮ Previous
Next ❯

Citations

Jul 29, 2011·Journal of Palliative Medicine·Egidio Del FabbroEduardo Bruera
Apr 5, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ShimizuY Uchitomi
Jun 16, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·José M GarciaSuzan Allen
Sep 10, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yu HuangShiying Yu
Aug 10, 2010·Current Opinion in Supportive and Palliative Care·Alessio MolfinoFilippo Rossi Fanelli
May 14, 2011·The American Journal of Geriatric Pharmacotherapy·David R Thomas
Jan 11, 2011·Critical Reviews in Oncology/hematology·David BlumUNKNOWN European Palliative Care Research Collaborative
Nov 16, 2010·Patient Education and Counseling·Sarah T HawleySteven J Katz
Jul 17, 2010·Medicina clínica·Albert Tuca RodríguezXavier Gómez-Batiste Alentorn
Jun 20, 2014·Journal of Ethnopharmacology·Te-Hsin ChaoUNKNOWN Evidence-based Chinese Medicine Research Group
Jun 7, 2011·Journal of Pain and Symptom Management·Mellar DavisRuth Lagman
Mar 13, 2015·Japanese Journal of Clinical Oncology·Ken ShimizuYosuke Uchitomi
Apr 28, 2017·Journal of Cachexia, Sarcopenia and Muscle·Susanne Blauwhoff-BuskermolenMarian A E de van der Schueren
Jun 24, 2016·The American Journal of Hospice & Palliative Care·Yong LiuJin Li
Mar 14, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·David HuiMasanori Mori
Jul 20, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S AliF H Sarkar
Jun 10, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Alessandro LavianoMarilia Seelaender
Mar 27, 2018·Journal of Cachexia, Sarcopenia and Muscle·Maria MaldonadoRamiro Salas
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ShimizuY Uchitomi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
David BlumEuropean Palliative Care Research Collaborative
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Mellar P DavisSusan LeGrand
International Journal of Cancer. Journal International Du Cancer
Ingvar BosaeusK Lundholm
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
William J EvansStefan D Anker
Journal of Pain and Symptom Management
Saskia C C M TeunissenAlexander de Graeff
© 2022 Meta ULC. All rights reserved