The cancer genetics and pathology of male breast cancer

Histopathology
Siddhartha DebStephen B Fox

Abstract

Male breast cancer (MBC) is an uncommon and poorly understood disease. Recent molecular studies have shown important differences from female breast cancer which are likely to influence treatment strategies from the current female-based management towards a more tailored approach. Significantly more MBCs than female breast cancers arise with an underlying germline cancer predisposition, and display a vastly different penetrance compared with females. Furthermore, the genophenotypical association of basal-like cancer with BRCA1 present in female breast cancer is not observed in male breast cancer. Differences in somatic changes between male and female breast cancer have also been reported, with particular enrichment of PIK3CA mutations and a paucity of TP53 mutations. In general, chromosomal-based changes, in particular regions of gains, are seen more frequently in male than female breast cancer and methylation is seen less frequently. Clinically, several molecular subtypes with prognostic relevance have been described, including chromosomal complex high and methylation high groups, and subgroups with profiling signatures pertaining to epithelial mesenchymal transition and hormonal therapy insensitivity. As with female breast can...Continue Reading

References

Aug 26, 1995·Lancet·S ThorlaciusJ E Eyfjord
May 1, 1995·Cancer·A AnelliP I Borgen
Sep 1, 1996·The Journal of Clinical Endocrinology and Metabolism·O HiortP Komminoth
Jan 1, 1997·British Journal of Cancer·E MavrakiN K Spurr
Jan 19, 1999·Genes, Chromosomes & Cancer·M TirkkonenA Borg
Apr 17, 1999·Breast Cancer Research and Treatment·J BoydH T Lynch
Mar 11, 2000·Journal of Medical Genetics·I E YoungC M Steel
Aug 30, 2000·Nature·C M PerouD Botstein
Jan 4, 2001·Human Mutation·E KwiatkowskaA Mackiewicz
Jan 6, 2001·Genetic Testing·R S SverdlovE Friedman
Mar 10, 2001·Journal of Medical Genetics·J D FackenthalO I Olopade
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Miguel de la HoyaTrinidad Caldés
Mar 7, 2002·Breast Cancer Research : BCR·Victoria M BashamPaul D P Pharoah
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas S FrankGregory C Critchfield
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Eliza KwiatkowskaAndrzej Mackiewicz
Feb 27, 2003·Breast Cancer Research and Treatment·Kirsi SyrjäkoskiPasi A Koivisto
Mar 26, 2003·Human Mutation·A Esra ManguogluEitan Friedman
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Kirsi SyrjäkoskiOlli-P Kallioniemi
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander LiedeSteven A Narod
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Apr 15, 2004·Journal of Korean Medical Science·Sei Hyun AhnByung Ho Son
May 8, 2004·Familial Cancer·Jan LubinskiSteven A Narod
Jun 29, 2004·Cancer·Sharon H GiordanoGabriel N Hortobagyi
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Maarit BärlundAnne Kallioniemi
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Kirsi SyrjäkoskiPasi A Koivisto
Dec 21, 2004·Breast Cancer Research and Treatment·Helen E MacLeanJeffrey D Zajac
May 18, 2005·The American Journal of Surgical Pathology·Peter T SimpsonSunil R Lakhani
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Christian RudlowskiLászló Füzesi
Jan 4, 2007·Nature Genetics·Nazneen RahmanMichael R Stratton
Jan 24, 2007·Breast Cancer Research : BCR·Lisa K DunnwaldChristopher I Li
Feb 9, 2007·Nature·Hannele ErkkoRobert Winqvist
Jul 20, 2007·Familial Cancer·D G R EvansFiona Lalloo
Jul 31, 2007·Breast Cancer Research and Treatment·Mario FalchettiLaura Ottini
Nov 21, 2007·Human Mutation·Silvia BenvenutiAlberto Bardelli
Nov 29, 2007·Journal of the National Cancer Institute·Yu Chuan TaiSining Chen
Jan 8, 2008·Breast Cancer Research and Treatment·Andreas Stang, Christoph Thomssen
Apr 29, 2008·Genetic Testing·Nikola BesicErik Teugels
Sep 2, 2008·Breast Cancer Research and Treatment·Marijke WasielewskiMieke Schutte
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 25, 2010·Breast Cancer Research and Treatment·Valentina SilvestriLaura Ottini
Mar 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael D WalshJoanne P Young

❮ Previous
Next ❯

Citations

Jun 10, 2016·British Journal of Cancer·Rebecca A Millican-SlaterThomas A Hughes
Dec 26, 2017·Acta Oncologica·Marianne D LautrupPeer Christiansen
Aug 25, 2017·Breast Cancer Research and Treatment·Guoqiao ZhengKari Hemminki
Jun 25, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lene Gaarsmand ChristensenAnne Marie Bak Jylling
Sep 10, 2020·Molecular Biology Reports·Wala Ben Kridis-RejebRaja Mokdad-Gargouri
Sep 13, 2017·BMC Cancer·Siddhartha DebStephen B Fox
Jun 18, 2018·Molecular Diagnosis & Therapy·Mingming LiangYehuan Sun
Apr 30, 2019·Molecular and Clinical Oncology·Saudade AndréAntónio E Pinto
Feb 29, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Anne Marie Bak JyllingMarianne Djernes Lautrup
Jul 7, 2020·Frontiers in Oncology·Maria P FoschiniRiccardo Masetti
Sep 16, 2016·Breast Cancer Research and Treatment·Anna Sara NavazioLaura Ottini
Mar 16, 2021·Medical Oncology·Noman Ahmed Jang Khan, Maria Tirona
Apr 9, 2021·Breast Cancer Research and Treatment·Andrew E JohnsonRachel B Jimenez
May 5, 2021·Breast Cancer Research and Treatment·Susana Nunes SilvaJosé Rueff
Aug 31, 2021·Virchows Archiv : an International Journal of Pathology·Stephen FoxAbeer M Shaaban
Apr 2, 2020·Breast Care·Francesca PelliniGiovanni Paolo Pollini

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.