The Cancer Genome Atlas Pan-Cancer analysis project

Nature Genetics
Cancer Genome Atlas Research NetworkJoshua M Stuart

Abstract

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.

References

Nov 14, 2013·Nature Communications·Mark P HamiltonSean E McGuire
Jun 17, 2014·Bioinformatics·Hsin-Ta WuBenjamin J Raphael
Apr 15, 2014·Nature Biotechnology·Jessica SeverinAlistair R R Forrest
Mar 15, 2014·Functional & Integrative Genomics·R AppelsG Keeble-Gagnere
Jul 6, 2014·Clinical Proteomics·Emily S Boja, Henry Rodriguez
Jun 20, 2014·Genome Medicine·Stephan Beck, Tony Ng
Feb 18, 2015·Nature Reviews. Cancer·David K ChangAndrew V Biankin
Jul 23, 2014·British Journal of Cancer·M P A DaviesH Haick
Aug 12, 2014·Epigenomics·Timo WittenbergerMartin Widschwendter
Aug 12, 2014·Trends in Pharmacological Sciences·Avi Ma'ayanYan Kou
Sep 4, 2014·Annual Review of Genomics and Human Genetics·Sameek Roychowdhury, Arul M Chinnaiyan
Sep 30, 2014·Nature Genetics·Nils WeinholdWilliam Lee
Dec 24, 2013·Biochimica Et Biophysica Acta·B PeschT Behrens
Sep 16, 2014·Current Problems in Cancer·Kevin E FisherMichael R Rossi
Jan 7, 2015·BMC Genomics·Alexandros ManolakosOlivier Gevaert
Jul 2, 2014·Analytical and Bioanalytical Chemistry·Alexandra J DickinsonNancy L Allbritton
Oct 31, 2014·Nature Methods·Javier A AlfaroPaul C Boutros
Dec 9, 2014·Epigenetics & Chromatin·Muhammad A ShahMatthieu Schapira
Jan 1, 2015·PeerJ·Jordan AnayaAnindya Dutta
Jan 26, 2016·Nature Reviews. Genetics·Charles GawadStephen R Quake
Jan 7, 2016·Human Molecular Genetics·Yanping ZhangDmitrij Frishman
Feb 16, 2016·Oncogenesis·Y ZhangJ Xu
Feb 18, 2016·Genomics, Proteomics & Bioinformatics·Yiwen Fang, Melissa J Fullwood
Nov 22, 2015·Nucleic Acids Research·Nicholas Paul GauthierMartin L Miller
Feb 16, 2016·Briefings in Bioinformatics·Khader ShameerJoel T Dudley
Nov 21, 2015·Nucleic Acids Research·Jonathan BurnsLaura F Landweber
Feb 16, 2016·Genomics, Proteomics & Bioinformatics·Pingjian Yu, Wei Lin
Jul 11, 2015·Expert Review of Molecular Diagnostics·Chun Man LiSze Chuen Cesar Wong
Feb 14, 2016·International Journal of Epidemiology·Cheng WangZhibin Hu
Jan 21, 2016·Expert Opinion on Drug Discovery·Gabriel Wajnberg, Fabio Passetti
Apr 1, 2015·Expert Opinion on Emerging Drugs·Yihui Wen, Jennifer R Grandis
Feb 24, 2016·Frontiers in Bioengineering and Biotechnology·Moriah E KattPeter C Searson
Aug 1, 2014·Nature·Greg Gibson
Oct 9, 2015·Critical Reviews in Biochemistry and Molecular Biology·Lijing YaoPeggy J Farnham
Feb 24, 2016·Frontiers in Bioengineering and Biotechnology·Bhanwar Lal PuniyaTomáš Helikar
Feb 13, 2016·Cancer Cell International·Chuance DuJia Li
Nov 25, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S W Piraino, S J Furney

Citations

Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ZagourasS Artavanis-Tsakonas
Jan 27, 2000·Cell·Douglas Hanahan, Robert A Weinberg
Aug 30, 2000·Nature·C M PerouD Botstein
Jun 18, 2002·Nature·Helen R DaviesP Andrew Futreal
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Aug 7, 2009·The New England Journal of Medicine·Elaine R MardisTimothy J Ley
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ultan McDermott, Jeff Settleman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanBRIM-3 Study Group
Jul 2, 2011·Nature·Cancer Genome Atlas Research Network
Jul 30, 2011·Science·Nicolas StranskyJennifer R Grandis
Oct 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Laura M HeiserPaul T Spellman
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nicholas J WangRaymond J Cho
Oct 20, 2011·Genome Research·Aleksandar D KosticMatthew Meyerson
Feb 14, 2012·Nature Medicine·Kengo TakeuchiYuichi Ishikawa
Mar 31, 2012·Nature·John N Weinstein
Jul 20, 2012·Nature·Cancer Genome Atlas Network
Sep 11, 2012·Nature·Cancer Genome Atlas Research Network
Sep 25, 2012·Nature·Cancer Genome Atlas Network
Feb 13, 2013·Clinical and Experimental Dermatology·G W M Millington
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Apr 2, 2013·Cell·Levi A Garraway, Eric S Lander
Apr 30, 2013·Cell·Sylvan BacaLevi A Garraway
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Jun 25, 2013·Nature·Cancer Genome Atlas Research Network
Jul 3, 2013·Genome Research·David A Wheeler, Linghua Wang
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Sep 17, 2013·Nature Methods·Matan HofreeTrey Ideker
Sep 17, 2013·Nature Methods·Jun LiHan Liang
Oct 3, 2013·Scientific Reports·David TamboreroNuria Lopez-Bigas

Related Concepts

Genome
Genomic Profile
Neoplasms
Study of Epigenetics
Malignant Neoplasms
MRNA Differential Display

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.