The Cancer Genome Atlas Project in Bladder Cancer

Cancer Treatment and Research
Alejo Rodriguez-VidaJoaquim Bellmunt

Abstract

Bladder cancer (BC) remains an aggressive disease with a poor prognosis, especially for patients with metastatic disease who have a limited median overall survival of 14 months. Urothelial carcinomas harbor frequent molecular dysregulations including recurrent mutations and copy number alteration, some of which could be potential therapeutic targets. However, no molecularly targeted agents have been approved to date for the treatment of advanced BC. Gaining new insights into the molecular landscape of BC will be critical to tailor future targeted agents for the treatment of advanced disease. The Cancer Genome Atlas (TCGA) project is cataloguing the genetic and epigenetic alterations responsible for cancer through the application of high-throughput genome analysis techniques. After the landmark paper profiling 131 patients was published in 2014, additional patients have been added with an updated TCGA analysis now including 412 patients. This chapter will review the previously described genomic alterations reported in the first manuscript and the new major highlights found in the expanded analyses recently published. The aim will be to review how this comprehensive integrated genomic analysis can inform the design of precision m...Continue Reading

Citations

Jan 11, 2019·International Journal of Cancer. Journal International Du Cancer·Wolfgang A SchulzAnnemarie Greife
Dec 8, 2019·Expert Review of Clinical Pharmacology·Kamaneh Montazeri, Joaquim Bellmunt
Sep 17, 2020·Expert Review of Clinical Pharmacology·Alberto D'AngeloGiandomenico Roviello
Jun 9, 2020·Cancer Immunology, Immunotherapy : CII·Qilai LongChong-Xian Pan
Dec 1, 2020·Expert Review of Anticancer Therapy·Kamaneh Montazeri, Guru Sonpavde
Jul 4, 2021·Urologic Oncology·Joseph JacobGennady Bratslavsky

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