The cancer-retina antigen recoverin as a potential biomarker for renal tumors

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Marina O GolovastovaPavel P Philippov

Abstract

The renal cell carcinoma is the ninth most common cancer with an increasing occurrence and mortality. Recoverin is the first retina-specific photoreceptor protein that was shown to undergo aberrant expression, due to its promoter demethylation, as a cancer-retina antigen in a number of malignant tumors. In this work, we demonstrated that recoverin is indeed expressed in 68.4 % of patients with different subtypes of renal cell carcinoma, and this expression has tendency to correlate with tumor size. Interestingly, 91.7 % of patients with the benign renal tumor, oncocytoma, express recoverin as well in their tumor. Epigenetic analysis of the recoverin gene promoter revealed a stable mosaic methylation pattern with the predominance of the methylated state, with the exception of -80 and 56 CpG dinucleotides (CpGs). While the recoverin expression does not correlate withoverall survival of the tumor patients, the methylation of the recoverin gene promoter at -80 position is associated with better overall survival of the patients. This work is the first report pointing towards the association of overall survival of renal cell carcinoma (RCC) patients with promoter methylation of a cancer-retina antigen. Taken together, these data allo...Continue Reading

References

Mar 24, 2000·Trends in Genetics : TIG·S B Baylin, J G Herman
Sep 7, 2002·International Journal of Cancer. Journal International Du Cancer·Ali O GüreYao-Tseng Chen
Nov 9, 2002·Bioinformatics·Long-Cheng Li, Rajvir Dahiya
Nov 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xavier LeroyMarie-Christine Copin
Apr 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alexandr V BazhinPavel P Philippov
Apr 1, 2005·Nature·Sarah Kimmins, Paolo Sassone-Corsi
Apr 26, 2005·Clinics in Laboratory Medicine·Ming ZhouCristina Magi-Galluzzi
Jan 25, 2006·International Journal of Cancer. Journal International Du Cancer·Andreas WadleChristoph Renner
Jan 31, 2006·Cancer Immunology, Immunotherapy : CII·Alexandr V BazhinStefan B Eichmüller
Dec 26, 2006·International Journal of Cancer. Journal International Du Cancer·Alexandr V BazhinStefan B Eichmüller
May 5, 2007·Journal of Carcinogenesis·Ekaterina B KuznetsovaVladimir V Strelnikov
Nov 6, 2007·Current Medicinal Chemistry·S B Eichmüller, A V Bazhin
Sep 25, 2008·International Journal of Cancer. Journal International Du Cancer·Alexandr V BazhinStefan B Eichmüller
Nov 6, 2009·Ophthalmic Research·Sachiyo MatsuoMitsuru Nakazawa
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 20, 2012·Nature Reviews. Urology·Prakash KulkarniRobert H Getzenberg
Oct 23, 2012·International Reviews of Immunology·Maurizio Chiriva-InternatiRead Alalawi
Dec 12, 2012·Critical Reviews in Immunology·Stefano CasertaRose Zamoyska
Jul 31, 2013·Journal of Cellular and Molecular Medicine·Patrícia PatrícioCarmen Jeronimo
Sep 13, 2013·The American Journal of Surgical Pathology·John R SrigleyUNKNOWN ISUP Renal Tumor Panel
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joo Mi YiNita Ahuja
Jan 8, 2014·International Journal of Cancer. Journal International Du Cancer·Thomas FleischerJörg Tost
Jan 24, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Ponniah SelvakumarAyyappan K Rajasekaran
Feb 4, 2014·BMC Cancer·Susan M MitchellPeter L Molloy
Nov 5, 2014·Biochemistry. Biokhimii︠a︡·M O GolovastovaP P Philippov
Nov 12, 2014·BMJ : British Medical Journal·Eric JonaschW Kimryn Rathmell
Jul 15, 2015·BioMed Research International·Rachna Raman, Daniel Vaena

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Citations

Jan 23, 2017·Current Urology Reports·Marina O GolovastovaAndrey A Zamyatnin
Jan 9, 2019·Bulletin of Experimental Biology and Medicine·E V Kochurova
Jan 30, 2018·Current Medicinal Chemistry·Alexey V BaldinLyudmila V Savvateeva
Aug 15, 2017·Epigenomics·Sophie C JoostenVivianne C Tjan-Heijnen
May 20, 2018·Molecular Diagnosis & Therapy·Brittany N Lasseigne, James D Brooks
Dec 1, 2020·Yonsei Medical Journal·Min DongAnkang Yin
Mar 5, 2021·Frontiers in Molecular Biosciences·Yuri M ShlyapnikovElena A Shlyapnikova
Apr 3, 2021·Ocular Oncology and Pathology·Sushant WagleySandra R Montezuma

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