The Candida albicans Biofilm Matrix: Composition, Structure and Function

Journal of Fungi
Christopher G PierceJosé L López-Ribot

Abstract

A majority of infections caused by Candida albicans-the most frequent fungal pathogen-are associated with biofilm formation. A salient feature of C. albicans biofilms is the presence of the biofilm matrix. This matrix is composed of exopolymeric materials secreted by sessile cells within the biofilm, in which all classes of macromolecules are represented, and provides protection against environmental challenges. In this review, we summarize the knowledge accumulated during the last two decades on the composition, structure, and function of the C. albicans biofilm matrix. Knowledge of the matrix components, its structure, and function will help pave the way to novel strategies to combat C. albicans biofilm infections.

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Citations

Jan 27, 2018·Journal of Fungi·Maria F AlonsoJudith M Bain
Feb 16, 2018·Assay and Drug Development Technologies·Archana Anandrao WakhardeSankunny Mohan Karuppayil
May 28, 2019·The Journal of Microbiology·Itzel Margarita Córdova-AlcántaraAida Verónica Rodriguez-Tovar
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Sep 18, 2021·ACS Medicinal Chemistry Letters·R Madison Green, Kevin L Bicker

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Methods Mentioned

BETA
electron microscopy
electrophoresis
Nuclear Magnetic Resonance

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