The candidate sex-reversing DAX1 gene is autosomal in marsupials: implications for the evolution of sex determination in mammals

Genomics
Andrew J PaskJ A Graves

Abstract

The human X-linked DAX1 gene was cloned from the region of the short arm of the human X found in duplicate in sex-reversed Xdup Y females (E. Zanaria et al., 1994, Nature 372: 635-641). DAX1 is suggested to be required for ovarian differentiation and to play an important role in mammalian sex determination or differentiation pathways. Its proposed dose-dependent effect on sexual development suggests that DAX1 could represent an evolutionary link with an ancestral sex-determining mechanism that depended on the dosage of an X-linked gene. Furthermore, DAX1 could also represent the putative X-linked switch gene, which independently controls sexual dimorphisms in marsupial mammals in an X-dose-dependent manner (D.W. Cooper et al., 1993, Semin. Dev. 4: 117-128). If DAX1 has a present role in marsupial sexual differentiation or had an ancestral role in mammalian sex determination, it would be expected to lie on the marsupial X chromosome, despite the autosomal localization of other human Xp genes. We therefore cloned and mapped the DAX1 gene in the tammar wallaby (Macropus eugenii). DAX1 was located on wallaby chromosome 5p near other human Xp genes, indicating that it was originally autosomal and that it is not involved in X-linked ...Continue Reading

References

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Citations

Aug 31, 2001·ILAR Journal·Paul B. Samollow
Oct 4, 2006·BMC Developmental Biology·Hongshi YuMarilyn B Renfree
Jan 26, 2016·Seminars in Cell & Developmental Biology·Deanne J Whitworth, Andrew J Pask
Dec 12, 2000·American Journal of Human Genetics·M PatelE R McCabe
Mar 8, 2000·Mechanisms of Development·B Capel
Dec 19, 2001·The Journal of Experimental Zoology·A Pask, M B Renfree
Jul 15, 1998·The Journal of Experimental Zoology·J A Graves
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J A Graves
Nov 21, 1998·Nature·A Swain, R Lovell-Badge
Mar 5, 1998·Nature·A SwainR Lovell-Badge
Nov 7, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Janine E DeakinJennifer A Marshall Graves
May 8, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R Toder, J A Graves
Jun 6, 2002·Trends in Genetics : TIG·Jennifer A Marshall Graves

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