The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra

PloS One
Margaret I DavisDavid M Lovinger

Abstract

Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning and control of motivated actions. However, the pattern of CB1-R expression across different striatal compartments, microcircuits and efferent targets, and the contribution of different CB1-R-expressing neurons to this pattern, are unclear. We use a combination of conventional techniques and novel genetic models to evaluate CB1-R expression in striosome (patch) and matrix compartments of the striatum, and in nigral targets of striatal medium spiny projection neurons (MSNs). CB1-R protein and mRNA follow a descending dorsolateral-to-ventromedial intensity gradient in the caudal striatum, with elevated expression in striosomes relative to the surrounding matrix. The lateral predominance of striosome CB1-Rs contrasts with that of the classical striosomal marker, the mu opioid receptor (MOR), which is expressed most prominently in rostromedial striosomes. The dorsolateral-to-ventromedial CB1-R gradient is similar to Drd2 dopamine receptor immunoreactivity and opposite to Substance P. T...Continue Reading

References

Aug 1, 1992·Journal of Neurochemistry·R T KennedyR M Wightman
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
May 15, 1985·The Journal of Comparative Neurology·S N HaberW J Nauta
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A I LeveyB J Ciliax
Oct 28, 1996·The Journal of Comparative Neurology·A E Kincaid, C J Wilson
Mar 12, 2002·The European Journal of Neuroscience·Michael Bubser, Ariel Y Deutch
Jan 31, 2004·The European Journal of Neuroscience·Henry H YinBernard W Balleine
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Esen SakaAnn M Graybiel
Sep 24, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hakim HouchiMickaël Naassila
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mai T DangYuqing Li
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne-Gaëlle CorbilléJean-Antoine Girault
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shiaoching GongCharles R Gerfen
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ana Belén MartínRosario Moratalla
Apr 15, 2008·Journal of Neuroscience Methods·Natasha L GrimseyE Scott Graham
May 23, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefano TavernaD James Surmeier
Jun 19, 2008·Annual Review of Neuroscience·Ann M Graybiel
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jan MulderTibor Harkany
Oct 30, 2008·Frontiers in Integrative Neuroscience·Monica R F HilárioRui M Costa
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wakoto MatsudaTakeshi Kaneko
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard W Balleine, John P O'Doherty
Oct 21, 2010·Alcoholism, Clinical and Experimental Research·Panayotis K ThanosNora D Volkow
Jun 11, 2011·Frontiers in Human Neuroscience·Ken-Ichi AmemoriAnn M Graybiel
Jun 12, 2012·Neuron·Mitsuko Watabe-UchidaNaoshige Uchida
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bradley D WintersYan Dong
Dec 5, 2012·Cold Spring Harbor Perspectives in Medicine·Alexander F Hoffman, Carl R Lupica
Dec 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Carola Sales-CarbonellDavid Robbe

❮ Previous
Next ❯

Citations

Jun 8, 2018·CNS Neuroscience & Therapeutics·Tiziana Marilena FlorioMarcello Alecci
Feb 14, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mary H PattonBrian N Mathur
Jul 28, 2020·The International Journal of Neuropsychopharmacology·Enzo Javier Pérez-ValenzuelaJosé Antonio Fuentealba Evans
Feb 16, 2019·Frontiers in Neuroscience·Gustavo Balbinot, Clarissa Pedrini Schuch
Jan 7, 2020·Annual Review of Psychology·Roy A Wise, Mykel A Robble
Sep 12, 2019·Physiological Reviews·Nora D VolkowRuben Baler
Sep 7, 2019·Journal of Neuroscience Research·Eric M Prager, Joshua L Plotkin
Jan 18, 2021·Psychopharmacology·Brandon D TurnerBrad A Grueter
Dec 18, 2018·Current Biology : CB·Simon HongAnn M Graybiel
Jun 24, 2020·Peptides·Richard J Bodnar
Dec 3, 2021·Journal of Biomedical Science·Roy A Wise, Chloe J Jordan

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
confocal microscopy

Key Resources (RRID) Mentioned

AB_409026
AB_2619969
AB_305866
AB_572251
AB_10013483

Software Mentioned

Adobe Photoshop CC
Prism
Frontier
GENSAT
Image J

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.