The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat.

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
R AbaloMaría Isabel Martín

Abstract

In the absence of pathology, cannabinoid-induced depression of gastrointestinal (GI) motility is thought to be mediated primarily by CB1 receptors, whereas the role of CB2 receptors is still unclear. The aim of this work was to radiographically analyze the acute effect of the mixed cannabinoid agonist WIN 55,212-2 (WIN) on GI motor function in the rat, focusing on the involvement of CB1 and CB2 receptors. Male Wistar rats received different doses of WIN and both psychoactivity (cannabinoid tetrad) and GI motility (radiographic analysis) were tested. The duration of WIN effect on GI motility was also radiographically analyzed. Finally, the involvement of the different cannabinoid receptors on WIN-induced alterations of GI motility was analyzed by the previous administration of selective CB1 (AM251) and CB2 (SR144528 or AM630) antagonists. After administration of contrast medium, alterations in GI motility were quantitatively evaluated in serial radiographs by assigning a compounded value to each region of the GI tract. Low, analgesic doses of WIN delayed intestinal transit, but high, psychoactive doses were required to delay gastric emptying. Acute WIN effects on GI motility were confined to the first few hours after administrat...Continue Reading

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Citations

Jan 15, 2013·Briefings in Functional Genomics·Brian M Forde, Paul W O'Toole
Feb 9, 2012·Neurochemical Research·Parichehr Hassanzadeh, Anna Hassanzadeh
Oct 22, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R GirónR Abalo
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM I Martín
Apr 13, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V Di Marzo, F Piscitelli
Feb 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM I Martín-Fontelles
Sep 22, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM Storr
May 23, 2012·Pharmacology, Biochemistry, and Behavior·Gema VeraRaquel Abalo
Mar 5, 2013·Pharmacology, Biochemistry, and Behavior·Gema VeraRaquel Abalo
Oct 1, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM I Martín-Fontelles
Mar 17, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I RamírezR Abalo
Mar 15, 2019·Journal of Neurogastroenterology and Motility·Susana Díaz-RuanoRaquel Abalo
Jun 16, 2012·Pharmacology·Raquel AbaloMaría Isabel Martín-Fontelles
May 23, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Gema VeraRaquel Abalo

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