The capacity of oocytes for DNA repair

Cellular and Molecular Life Sciences : CMLS
Jessica M StringerK J Hutt

Abstract

Female fertility and offspring health are critically dependent on the maintenance of an adequate supply of high-quality oocytes. Like somatic cells, oocytes are subject to a variety of different types of DNA damage arising from endogenous cellular processes and exposure to exogenous genotoxic stressors. While the repair of intentionally induced DNA double strand breaks in gametes during meiotic recombination is well characterised, less is known about the ability of oocytes to repair pathological DNA damage and the relative contribution of DNA repair to oocyte quality is not well defined. This review will discuss emerging data suggesting that oocytes are in fact capable of efficient DNA repair and that DNA repair may be an important mechanism for ensuring female fertility, as well as the transmission of high-quality genetic material to subsequent generations.

References

Dec 1, 1978·The Journal of Experimental Zoology·Y Hirao, R Yanagimachi
Feb 1, 1992·Molecular and Cellular Biology·W GoedeckeP Pfeiffer
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J W Drake
Sep 1, 1990·Mutation Research·K Sakumi, M Sekiguchi
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I VarletP Brooks
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W Xiao, L Samson
Oct 1, 1995·Trends in Biochemical Sciences·E SeebergM Bjørås
Apr 19, 1996·The Journal of Biological Chemistry·G FrosinaE Dogliotti
Jun 28, 1996·Cell·W EdelmannR Kucherlapati
Jul 12, 1996·Cell·C BarlowA Wynshaw-Boris
Mar 4, 1997·Mutation Research·D L CheoE C Friedberg
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T NouspikelS G Clarkson
Jan 1, 1997·Annual Review of Immunology·M F Lavin, Y Shiloh
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J M de MurciaG de Murcia
Aug 1, 1997·Fertility and Sterility·A S Lim, M F Tsakok
Oct 6, 1997·Genes & Development·Z Q WangE F Wagner
Jan 22, 1998·Mutation Research·D E McFadden, J M Friedman
Aug 14, 1998·Molecular Cell·G C LiC Cordon-Cardo
Jan 23, 1999·Nature Genetics·W EdelmannR Kucherlapati
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KurimasaG C Li
Mar 11, 1999·Current Opinion in Genetics & Development·R D Kolodner, G T Marsischky
Mar 19, 1999·Molecular and Cellular Biology·P Labhart
Apr 13, 1999·The American Journal of Physiology·M TakamiH R Behrman
Jun 11, 1999·The Journal of Biological Chemistry·J C AméG de Murcia
Jun 26, 1999·Chromosoma·P B MoensA Wynshaw-Boris
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M Simbulan-RosenthalM E Smulson

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Citations

Aug 8, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jessica M StringerKarla J Hutt
Jan 17, 2019·Genes·Tiphanie CavéGuylain Boissonneault
Jan 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Amy L WinshipKarla J Hutt
Jul 22, 2019·Human Genetics·Taylor McNeelyIsabel Beerman
Jul 1, 2019·Chromosoma·Berta N VazquezKaren Schindler
Dec 24, 2018·International Journal of Molecular Sciences·Anaís García-RodríguezStephen Johnston
Oct 1, 2020·Genes·Evgenia V KhokhlovaElena I Leonova
May 15, 2020·Journal of Assisted Reproduction and Genetics·Carlotta ZacàAndrea Borini
Jun 3, 2020·Journal of Medical Genetics·Sandrine CaburetMicheline Misrahi
Jan 14, 2021·Cell Reports·Mariangela SabatellaHannes Lans
Feb 2, 2021·Science Advances·José M Navarro-PandoMario D Cordero
Mar 19, 2021·Zygote : the Biology of Gametes and Early Embryos·Amanda Souza SettiEdson Borges
Apr 8, 2021·Fertility and Sterility·Evelyn E Telfer, Claus Yding Andersen
Aug 19, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Guy MorrisSrividya Seshadri
Aug 21, 2021·Journal of Cell Science·Ajay K SinghH B D Prasada Rao
Jan 13, 2022·Human Reproduction Update·Richard MussonGrażyna Ewa Ptak

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Methods Mentioned

BETA
RNA-seq
glycosylases
X-ray
chromosomal aberrations

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