PMID: 3756358Oct 1, 1986Paper

The capacity of various types of immunoglobulin for intravenous use to interact with Fc receptors of human monocytes and macrophages

Blut
T W JungiS Barandun

Abstract

The capacity of immunoglobulin for intravenous application (IgG-IV) to interact with Fc receptors of human monocytes and macrophages was tested by quantifying the inhibition of phagocytosis of IgG-sensitized erythrocytes. To this end a spectrometric phagocytosis test has been used. When compared with IgG for i.m. use (IgG-IM), all IgG-IV had reduced activity. This reduction was related, in part, to the reduced amount of IgG dimers and polymers in IgG-IV. On a weight basis dimeric IgG and polymeric IgG exerted 6-fold and 14-fold higher activity, respectively, than monomeric IgG. When this difference was corrected for, chemically modified IgG-IV still had significantly reduced inhibitory activity; DEAE-Sephadex-treated IgG and acid-treated IgG had an activity similar to IgG-IM, and PEG-treated IgG showed a slightly reduced activity. Pepsin-treated IgG was greater than 100-fold less active than IgG-IM. The reactivity of IgG-IV with monocyte and macrophage Fc receptors was closely correlated. The most conspicuous differences found were related to the concentration at which IgG was used. Thus, beta-propiolactone-treated IgG and plasmin-treated IgG were found to have significantly reduced activity at concentrations greater than 20 mi...Continue Reading

References

Mar 1, 1985·Molecular Immunology·D R Burton
Feb 1, 1983·British Journal of Haematology·B GrossU E Nydegger
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H B FleitJ C Unkeless

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Citations

May 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·R I Schiff
Mar 1, 1992·Antimicrobial Agents and Chemotherapy·A N Neely, I A Holder
Oct 23, 2008·Immunology and Allergy Clinics of North America·Martha M Eibl
Jan 27, 2009·The International Journal of Biochemistry & Cell Biology·Amin Majdalawieh, Hyo-Sung Ro

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