PMID: 2157673Apr 15, 1990

The capsule surrounding primary liver tumors: wherefrom its prognostic significance?

International Journal of Cancer. Journal International Du Cancer
W F GrigioniS Garbisa


Primary liver neoplasms in cirrhotic and non-cirrhotic patients were studied by electron microscopy and immunohistochemical methods for extracellular matrix (ECM) antigens. A capsule of variable thickness was present in many expanding hepatocellular carcinomas, while it was absent in those of small size, and either fragmented or absent in the infiltrating ones. In the capsules of early onset, fibronectin was the most frequent stromal glycoprotein. In the completely formed capsular structures, fibronectin, type-V collagen and laminin were the most common macromolecules seen. No differences were evident in the pattern of ECM macromolecules in the capsules surrounding hepatocellular carcinomas compared with those found in benign lesions, such as hepatocellular adenomas or focal nodular hyperplasia. The possibility is discussed that the capsule could be a result of the following sequence: tissue with expansive (not infiltrative) growth-mechanical compression-ischemic necrosis of surrounding tissues-repair process with ECM deposition.


May 20, 2003·Journal of Gastroenterology and Hepatology·David S R LockwoodDavid C Gotley
Jun 3, 2008·Carcinogenesis·F TrevisaniM Bernardi
Sep 5, 2008·The American Journal of Surgical Pathology·Tomohiro IguchiMasazumi Tsuneyoshi
Mar 10, 2009·Annals of Surgical Oncology·Steven C CunninghamTimothy M Pawlik
Dec 14, 2011·Journal of Surgical Oncology·Tsung-Han WuMiin-Fu Chen


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Related Concepts

Microbial Anatomical Capsule Structure
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Electron Microscopy, Diagnostic

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