PMID: 2157673Apr 15, 1990

The capsule surrounding primary liver tumors: wherefrom its prognostic significance?

International Journal of Cancer. Journal International Du Cancer
W F GrigioniS Garbisa

Abstract

Primary liver neoplasms in cirrhotic and non-cirrhotic patients were studied by electron microscopy and immunohistochemical methods for extracellular matrix (ECM) antigens. A capsule of variable thickness was present in many expanding hepatocellular carcinomas, while it was absent in those of small size, and either fragmented or absent in the infiltrating ones. In the capsules of early onset, fibronectin was the most frequent stromal glycoprotein. In the completely formed capsular structures, fibronectin, type-V collagen and laminin were the most common macromolecules seen. No differences were evident in the pattern of ECM macromolecules in the capsules surrounding hepatocellular carcinomas compared with those found in benign lesions, such as hepatocellular adenomas or focal nodular hyperplasia. The possibility is discussed that the capsule could be a result of the following sequence: tissue with expansive (not infiltrative) growth-mechanical compression-ischemic necrosis of surrounding tissues-repair process with ECM deposition.

References

May 20, 2003·Journal of Gastroenterology and Hepatology·David S R LockwoodDavid C Gotley
Jun 3, 2008·Carcinogenesis·F TrevisaniM Bernardi
Sep 5, 2008·The American Journal of Surgical Pathology·Tomohiro IguchiMasazumi Tsuneyoshi
Mar 10, 2009·Annals of Surgical Oncology·Steven C CunninghamTimothy M Pawlik
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Citations

May 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B ClementA Guillouzo
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S L FriedmanD M Bissell
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K SakakibaraT Hatahara
Jan 1, 1984·Acta Pathologica Japonica·M YamamotoE Tahara
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F B BianchiS Garbisa
Mar 1, 1981·The Journal of Cell Biology·H K KleinmanG R Martin

Related Concepts

Microbial Anatomical Capsule Structure
Glycoproteins
Liver Carcinoma
Extracellular Matrix
Fibrosis, Liver
Liver Diseases
Infiltration
Electron Microscopy, Diagnostic
Antigens
Macromolecule

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