The Carbamate, Physostigmine does not Impair Axonal Transport in Rat Cortical Neurons.

Neuroscience Insights
Sean X NaughtonA V Terry

Abstract

Among the various chemicals that are commonly used as pesticides, organophosphates (OPs), and to a lesser extent, carbamates, are most frequently associated with adverse long-term neurological consequences. OPs and the carbamate, pyridostigmine, used as a prophylactic drug against potential nerve agent attacks, have also been implicated in Gulf War Illness (GWI), which is often characterized by chronic neurological symptoms. While most OP- and carbamate-based pesticides, and pyridostigmine are relatively potent acetylcholinesterase inhibitors (AChEIs), this toxicological mechanism is inadequate to explain their long-term health effects, especially when no signs of acute cholinergic toxicity are exhibited. Our previous work suggests that a potential mechanism of the long-term neurological deficits associated with OPs is impairment of axonal transport (AXT); however, we had not previously evaluated carbamates for this effect. Here we thus evaluated the carbamate, physostigmine (PHY), a highly potent AChEI, on AXT using an in vitro neuronal live imaging assay that we have previously found to be very sensitive to OP-related deficits in AXT. We first evaluated the OP, diisopropylfluorophosphate (DFP) (concentration range 0.001-10.0 ...Continue Reading

References

Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Pamela EspositoTheoharis C Theoharides
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Beatrice Alexandra Golomb
May 1, 2005·Environmental Toxicology and Pharmacology·Carey PopeJing Liu
Jul 1, 2008·Environmental Toxicology and Pharmacology·Dongsun ParkYun-Bae Kim
Jan 25, 2012·Neurotoxicology·Leslie LondonLorann Stallones
Apr 6, 2013·Journal of Toxicology and Environmental Health. Part a·Mohamed B Abou-DoniaMichel F A Mulder
Nov 7, 2014·Neuron·Sandra MadayErika L F Holzbaur
Dec 17, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Joseph W WatkinsUNKNOWN Toxicology Investigators Consortium investigators
Oct 24, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Roberta F WhiteRachel Grashow
Jan 1, 2016·The Journal of Pharmacology and Experimental Therapeutics·Jie GaoAlvin V Terry
Mar 19, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Virginia A Rauh, Amy E Margolis
Mar 14, 2017·Neurotoxicology and Teratology·Mohamed B Abou-DoniaKimberly Sullivan
Jul 14, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ann M ArensTom Kearney
Sep 7, 2017·Neurotoxicity Research·Heba Allah Abd El RahmanMohamed B Abou-Donia
Dec 6, 2017·Environmental Science and Pollution Research International·Leila MohammadzadehBibi Marjan Razavi
Dec 12, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lucio G Costa
Jan 30, 2019·International Journal of Environmental Research and Public Health·Lars-Gunnar Gunnarsson, Lennart Bodin
Feb 13, 2019·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Ann M Arens, Tom Kearney
Mar 17, 2019·Journal of Cell Science·Mara A Olenick, Erika L F Holzbaur

❮ Previous
Next ❯

Software Mentioned

KymoAnlyzer
FIJI
Kymograph Action Tool
KymoAnalyzer
ImageJ
Zen
GraphPad Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.