PMID: 11931017Apr 5, 2002Paper

The carbohydrate moiety of serum IgM from Atlantic cod (Gadus morhua L.)

Fish & Shellfish Immunology
Bergljót MagnadóttirP M Rudd

Abstract

The carbohydrate moiety of cod serum IgM was analysed using oligosaccharide sequencing techniques. The carbohydrate moiety constituted about 10% of the molecular weight of cod IgM, was associated with the constant region of the heavy chains (Fc), and was composed of N-linked complex type oligosaccharides. Considerable heterogeneity was observed. Sixteen different glycan structures were identified, over 60% were sialylated and 40% contained core fucose. The carbohydrate moiety of cod IgM was shown to provide protection against protease digestion, and partial deglycosylation abolished the antigen binding property of natural cod anti-TNP-BSA antibody.

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Citations

May 4, 2007·Fish & Shellfish Immunology·Anita RønnesethEirin Fausa Pettersen
Dec 21, 2005·Developmental and Comparative Immunology·Anil ThankappanThomas J McConnell
Aug 9, 2005·Developmental and Comparative Immunology·Stein Tore Solem, Jørgen Stenvik
Nov 5, 2016·Fish & Shellfish Immunology·Sumaira BilalIvar Hordvik
Apr 15, 2010·Marine Biotechnology·Gary S Caldwell, Helen E Pagett
Nov 30, 2018·Frontiers in Immunology·Yi-Ling SuHui Geng

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