The carboxyl third of tau is tightly bound to paired helical filaments.

Neuron
J KondoY Ihara

Abstract

To obtain definitive evidence that tau is a component of paired helical filaments (PHF) in Alzheimer's disease, we fractionated and sequenced PHF-derived peptides according to a previously described procedure. In the PHF digest, we found four independent tau peptides that were located in the carboxyl third of tau. Subsequent extensive analysis of the PHF digest did not provide any other tau peptides. The conventional PHF antiserum and a new antiserum directed toward formic acid-denatured PHF reacted with the distinct CNBr fragments of tau localized on the carboxy-terminal portion of tau by protein sequencing. From these observations, we conclude that the carboxyl third of tau is tightly bound to PHF.

References

Feb 1, 1976·Journal of the Neurological Sciences·H M WiśniewskiR D Terry
Dec 1, 1985·Journal of Biochemistry·N Nukina, Y Ihara
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G WoodL I Binder
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C M WischikR A Crowther
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C M WischikA Klug
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D A KirschnerD J Selkoe
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Mar 1, 1981·Journal of the Neurological Sciences·B E TomlinsonG Blessed
Aug 1, 1981·Annals of Neurology·R D TerryD S Horoupian

❮ Previous
Next ❯

Citations

Nov 5, 1999·Cell Motility and the Cytoskeleton·H G Tomasiewicz, J G Wood
Oct 23, 2002·Journal of Neuroscience Research·Maho Morishima-Kawashima, Yasuo Ihara
Dec 1, 1989·Journal of Neuroscience Research·M DammermanB Shafit-Zagardo
Mar 1, 1990·Journal of Neuroscience Research·H Ksiezak-RedingS H Yen
Aug 1, 1995·Journal of Neuroscience Research·H Ksiezak-RedingS H Yen
Mar 1, 1990·Cellular and Molecular Neurobiology·M Goedert, M G Spillantini
Jan 1, 1993·Molecular Neurobiology·L C Doering
Jul 19, 1991·Brain Research·M Morishima-KawashimaY Ihara
Dec 6, 1991·Brain Research·G P WangI Grundke-Iqbal
Sep 25, 1995·Journal of Immunological Methods·E KontsekovaM Novak
Sep 1, 1989·Journal of the Neurological Sciences·D M MannM Landon
Jan 1, 1992·Pharmacology & Therapeutics·A I BushC L Masters
May 1, 1991·Trends in Neurosciences·M GoedertC C Garner
Nov 1, 1993·Trends in Neurosciences·M Goedert
Nov 10, 1992·Biochimica Et Biophysica Acta·J P Brion
Sep 1, 1994·Archives of Gerontology and Geriatrics·Y Ihara
Nov 1, 1993·Brain Research. Molecular Brain Research·L A SygowskiC B Caputo
Mar 1, 1995·Brain Research. Molecular Brain Research·F OyamaY Ihara
Nov 1, 1994·Brain Research. Molecular Brain Research·A SawaY Ihara
Jan 1, 1994·Neurobiology of Aging·H Ksiezak-Reding, J S Wall
May 1, 1995·Neurobiology of Aging·M GoedertP Cohen
May 1, 1995·Neurobiology of Aging·M Morishima-KawashimaY Ihara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.