PMID: 6966271Mar 1, 1980Paper

The carcinogenic effect of localized fission fragment irradiation of rat lung

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
A L BatchelorM R Bailey

Abstract

In a preliminary investigation of 'hot particle' carcinogenesis uranium oxide particles were introduced into the lungs of rats either by intubation of a liquid suspension of the particles or by inhalation of an aerosol. Subsequently the animals were briefly exposed to slow neutrons in a nuclear reactor, resulting in localized irradiation of the lung by fission fragments emitted from 235U atoms in the oxide particles. The uranium used in the intubation experiments was either enriched or depleted in 235U. Squamous cell carcinomas developed at the site of deposition of the enriched uranium oxide in many cases but no lung tumours occurred in the rats with the depleted uranium oxide, in which the lung tissue was exposed to very few fission fragments. Only enriched uranium oxide was used in the inhalation experiments. Pulmonary squamous cell carcinomas occurred after the fission fragment irradiation but were fewer than in the intubation experiments. Adenocarcinomas of the lung were seen in rats exposed to uranium oxide without subsequent irradiation by neutrons in the reactor and in rats irradiated with neutrons but not previously exposed to uranium oxide. It is concluded that (i) fission fragments were possibly implicated in the gen...Continue Reading

References

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Citations

Jun 19, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Elena CraftMohamed Abou-Donia
Nov 1, 1980·Physics in Medicine and Biology·D J Gore, T J Jenner
Jul 1, 1982·Physics in Medicine and Biology·A L BatchelorD G Papworth

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