PMID: 3753032Jan 1, 1986Paper

The carcinogenic properties of topical PUVA. A lifelong study in mice

Archives of Dermatological Research
M HannukselaA Lahti

Abstract

The tumorigenic properties of topical methoxsalen (8-MOP) and trioxsalen (TMP) plus ultraviolet light A (UVA) were studied in NMRI female mice. The animals were treated three times weekly for 9 months, and followed up for 18 months. Acetonic solutions of TMP (0.1 mg in 0.2 ml) and 8-MOP (0.6 mg in 0.2 ml) were applied to the shaved back skin of the mice and irradiated with UVA. The doses needed to elicit equivalent phototoxic effects were 0.29 J/cm2 in the TMP group and 1.09 J/cm2 in the 8-MOP group. Papillomas, keratoacanthomas, and squamous cell carcinomas developed in the 8-MOP group only, and the first tumor was seen at 10 months after the beginning of the study. The results suggest that the carcinogenicity of these two modes of photochemotherapy may differ.

References

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Citations

Oct 6, 1997·Clinics in Dermatology·J Lauharanta
Jun 26, 2001·Clinical and Experimental Dermatology·H Hönigsmann
Oct 1, 1992·The British Journal of Dermatology·P Collins, S Rogers
May 13, 1999·Journal of the American Academy of Dermatology·A Hannuksela-SvahnJ Karvonen
Nov 1, 1996·Journal of the American Academy of Dermatology·A HannukselaJ Karvonen
Jan 1, 1995·International Archives of Occupational and Environmental Health·M DaleneP Brunmark
Jan 1, 1995·International Archives of Occupational and Environmental Health·P BrunmarkG Skarping
Dec 22, 1999·Seminars in Cutaneous Medicine and Surgery·W L Morison
Mar 25, 2000·Clinical and Experimental Dermatology·T BasarabJ N Barker

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