The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells

Molecular Cancer Therapeutics
Tatjana MijatovicRobert Kiss

Abstract

Non-small cell lung cancers (NSCLC) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and Vinca alkaloid derivatives, offers patients only slight clinical benefits. Part of the chemoresistance of NSCLCs results from the constitutive or anticancer drug-induced activation of the nuclear factor-kappaB (NF-kappaB) signaling pathways. The present study shows that human A549 NSCLC cells display highly activated cytoprotective NF-kappaB signaling pathways. UNBS1450, which is a cardenolide belonging to the same class of chemicals as ouabain and digitoxin, affected the expression and activation status of different constituents of the NF-kappaB pathways in these A549 tumor cells. The modifications brought about by UNBS1450 led to a decrease in both the DNA-binding capacity of the p65 subunit and the NF-kappaB transcriptional activity. Using the 3-(4,5-dimethylthiazol-2yl)-dephenyltetrazolium bromide colorimetric assay, we observed in vitro that UNBS1450 was as potent as taxol and SN38 (the active metabolite of irinotecan) in reducing the overall growth levels of the human A549 NSCLC cell line, and was more efficient than platin derivatives, including cisplatin, carboplatin, and o...Continue Reading

References

Oct 1, 1992·Planta medica·N KanedaV Reutrakul
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·T OhmoriN Saijo
Aug 25, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·W R SmytheS M Albelda
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SperandioD E Bredesen
Aug 7, 2001·Anti-cancer Drugs·B Stenkvist
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·O AizmanA Aperia
Mar 28, 2002·Physiological Reviews·Michael H Glickman, Aaron Ciechanover
May 25, 2002·European Journal of Biochemistry·Zijian Xie, Amir Askari
May 25, 2002·European Journal of Biochemistry·Wilhelm Schoner
Aug 23, 2002·Experimental Biology and Medicine·Renata I Dmitrieva, Peter A Doris
Oct 9, 2002·Current Medicinal Chemistry·C GridelliA Rossi
Sep 17, 2003·Genes & Development·Patrick G HoganAnjana Rao
Dec 31, 2003·Molecular Biology of the Cell·Cromwell E EspinedaAyyappan K Rajasekaran
Feb 14, 2004·The Journal of Biological Chemistry·Haojie WangZijian Xie
Apr 13, 2004·Oncogene·Klaus-Michael Debatin, Peter H Krammer
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Meera SrivastavaHarvey B Pollard
Jun 15, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·David BlancoLuis M Montuenga
Aug 3, 2004·Nature Reviews. Cancer·Hitoshi Okada, Tak W Mak
Aug 18, 2004·The Journal of Experimental Medicine·Jesper NylandstedMarja Jäättelä
Sep 24, 2004·Cancer Cell·Bharat B Aggarwal
Apr 2, 2005·Nature Reviews. Cancer·Chikashi Nakanishi, Masakazu Toi
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Maarten L JanmaatGiuseppe Giaccone

❮ Previous
Next ❯

Citations

Jun 12, 2013·Investigational New Drugs·M SlingerlandH Gelderblom
Dec 29, 2011·Pharmaceutical Research·Lokesh NagaprashanthaSharad S Singhal
Nov 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Huafeng ZhangGregg L Semenza
Feb 13, 2010·Neuro-oncology·Marie-Thérése StockhausenHans Skovgaard Poulsen
Apr 25, 2012·World Journal of Gastroenterology : WJG·Jun-Li GuoHao-Fu Dai
Jun 5, 2014·BioMed Research International·José Manuel Calderón-MontañoMiguel López-Lázaro
May 19, 2012·Expert Opinion on Therapeutic Patents·Hua-Yu Leo Wang, George A O'Doherty
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Miguel López-Lázaro
Oct 15, 2008·Expert Opinion on Therapeutic Targets·Tatjana MijatovicRobert Kiss
May 15, 2009·The American Journal of the Medical Sciences·M Iltaf KhanDonald M Miller
Jun 28, 2012·Mitochondrion·Claudia CerellaMarc Diederich
Nov 1, 2011·Toxicology and Applied Pharmacology·Hosam A ElbazYon Rojanasakul
Jun 23, 2006·Neoplasia : an International Journal for Oncology Research·Tatjana MijatovicRobert Kiss
Sep 21, 2010·Biochemical Pharmacology·Tom JunckerMarc Diederich
Apr 3, 2009·Cancer Letters·Tatjana MijatovicWalter Berger
Mar 28, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dong WangYun-Song Zhang
Sep 16, 2006·Biochemical Pharmacology·Sabine OlivierVincent Bours
Jul 16, 2013·Steroids·Hanyun YouLihong Hu
Mar 24, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Maen ZeinoThomas Efferth
Aug 21, 2007·Biochimica Et Biophysica Acta·Tatjana MijatovicRobert Kiss
Mar 3, 2009·Biochimica Et Biophysica Acta·Régis GasperErik Goormaghtigh
Nov 16, 2012·Natural Product Reports·Jorge A R SalvadorM Luisa Sá e Melo
Jun 19, 2014·Natural Product Research·Gamal A MohamedDiaa T A Youssef
Apr 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Xianzhou SongJin Wang
May 12, 2016·Fitoterapia·Shiyuan WenMiaomiao Jiang
Jul 18, 2016·European Biophysics Journal : EBJ·Emily G Thompson, Harald Sontheimer
Aug 25, 2016·Biochemical Pharmacology·Marc DiederichClaudia Cerella
Feb 28, 2008·Neurosurgery·Florence LefrancRobert Kiss
Apr 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cassiano Felippe Gonçalves-de-AlbuquerquePatrícia Burth
Aug 22, 2018·Expert Opinion on Investigational Drugs·Yu-Long LanBo Zhang
Oct 25, 2008·Nature Reviews. Drug Discovery·Ioannis Prassas, Eleftherios P Diamandis
May 15, 2007·American Journal of Physiology. Cell Physiology·Wilhelm Schoner, Georgios Scheiner-Bobis
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dhanasekhar ReddyPreetam Ghosh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.