PMID: 8970577Nov 1, 1996Paper

The cardiac endothelium: cardioactive mediators

Progress in Cardiovascular Diseases
A M ShahW J Paulus

Abstract

Endothelial cells within the heart release a number of substances that modulate myocardial contractile function. These agents include nitric oxide, endothelin, prostanoids, adenylpurines, and other substances that have so far been characterized only in bioassay studies. A notable feature of many of these agents is that they influence contractile behavior predominantly by modifying cardiac myofilament properties rather than altering cytosolic Ca2+ transients. A consequence of this subcellular action is often a disproportionate effect on myocardial relaxation and diastolic tone. The paracrine modulation of cardiac myocyte function by endothelial cell factors is likely to be an important mechanism contributing to the overall regulation of cardiac contractile function, both physiologically and in pathological states.

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Citations

Apr 6, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Adam D Durbin, Avrum I Gotlieb
Jun 28, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M RadisicG Vunjak-Novakovic
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May 10, 2007·Canadian Journal of Physiology and Pharmacology·Danielle Jacques, Dima Abdel-Samad
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Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·Danielle JacquesChantale Provost
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Oct 25, 2020·Tissue Engineering. Part B, Reviews·Pamela Hitscherich, Eun Jung Lee
Feb 22, 2021·Journal of Cellular and Molecular Medicine·Wenhua LeiMao Chen

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