Feb 1, 1989

The cardiocirculatory and metabolic effects of endotoxin challenge after canine resuscitated hemorrhagic shock

The Journal of Trauma
J W Horton

Abstract

Although adequate volume resuscitation has decreased mortality from hemorrhagic shock, recovery in many patients is complicated by sepsis. To determine whether a subject debilitated by hemorrhagic shock would exhibit greater cardiocirculatory dysfunction when challenged with sepsis, ten dogs (Group I) were hemorrhaged to a mean arterial blood pressure of 30 mm Hg. After 2 hours of hypotension, shed blood and lactated Ringer's solution (50 ml/kg) were given, and the dogs were observed for 3 to 6 days. Ten dogs were sham hemorrhage and served as controls (Group II). On the experimental day, all cardiovascular and hemodynamic parameters were measured in both groups of animals before endotoxin challenge. There was no significant difference in cardiac output, stroke volume, stroke work, +dP/dt max, myocardial blood flow, myocardial oxygen metabolism, or acid-base balance in the two groups. Compared to sham-hemorrhaged dogs, resuscitated shock dogs had a significantly lower mean arterial blood pressure (127 +/- 7 vs. 110 +/- 6 mm Hg; p less than 0.05), and heart rate was significantly higher (86 +/- 6 vs. 109 +/- 7 beats/minute; p less than 0.05). Furthermore, maximal rate of left ventricular pressure fall (-dP/dT max) was significan...Continue Reading

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Mentioned in this Paper

Septicemia
Evaluation of Acid-base Balance
Salicylhydroxamic acid
Alkalescens-Dispar Group
Catecholamine [EPC]
Ventricular Dysfunction, Left
Myocardium
Shock
Thyroid Hormone Plasma Membrane Transport Defect
Oxygen Metabolic Process

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